ArticleResearch square2025
Distinct Neural Mechanisms in the Propagation of Itch in the Face and Body.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
Abstract
Itch intensity, quality and characteristics differ between body regions. Despite their prevalence, the mechanisms underlying regional itch differences remain poorly understood. Here, we investigate the neural basis of regional differences, focusing on the functional role of neuropeptides and histamine receptors expression in trigeminal ganglia versus dorsal root ganglia innervating afferents to cheek and the neck. Using an interdisciplinary approach, we identified distinct regional differences between the cheeks and necks of mice and humans. Our findings reveal that Substance P modulates itch in the cheek, while histamine receptor 1 (HRH1) is the primary receptor mediating itch but not pain in the cheek. We also discovered regional differences in sensory neuron subpopulations, with increased co-expression of HRH1 and neuropeptides in trigeminal ganglion neurons. Our study provides new insights into the molecular and cellular mechanisms underlying regional itch differences, supporting region-specific treatment strategies for skin and systemic diseases.
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Registered trials
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