Evidence mapPaperPMID 40386389Full record

ArticleResearch square2025

Dissecting Metabolic Control of Behaviors and Physiology During Aging in Drosophila.

Elizabeth S Pasam, Kishore Madamanchi, Girish C Melkani

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Elizabeth S PasamUniversity of Alabama at Birmingham.
Kishore MadamanchiUniversity of Alabama at Birmingham.
Girish C MelkaniUniversity of Alabama at Birmingham.

Funding

Promoting circadian rhythms to optimize gut-to-brain signaling for Alzheimer's diseaseRF1NS133378 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Girish C. Melkani · 2023 to 2023
$1.9M
NIA NIH HHS R01 AG065992NINDS NIH HHS RF1 NS133378
6 · The paper itself

Abstract

Aging disrupts physiological and behavioral homeostasis, largely driven by one-carbon metabolism, mitochondrial dysfunction, energy sensing, and metabolic imbalance. To elucidate the roles of conserved metabolic, energy sensing, and mitochondrial genes in age-related decline, we employed genetic manipulations

Indexed as

Agingcircadian rhythmlipid metabolismmitochondrial dysfunctionsleep fragmentation

Identifiers

PMID40386389
PMCPMC12083682

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.