Evidence map›Paper›PMID 40386394›Full record

ArticleResearch square2025

Interaction between Infection of Porphyromonas gingivalis, A Keystone Microbe of Oral Microbiome, and Serum Levels of Lutein/Zeaxanthin Is Associated with Risk for Age-related Macular Degeneration.

Chung-Jung Chiu, Emily Chiu, Min-Lee Chang

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Chung-Jung ChiuThe Forsyth Institute.
Emily ChiuThe University of Vermont.
Min-Lee ChangHarvard Medical School.

Funding

Development of a prediction model for advanced age-related macular degenerationR01EY021826 · NEI · TUFTS UNIVERSITY BOSTON · PI CHIU, CHUNG-JUNG · 2011 to 2013
$1.2M
Infections of specific periodontal microbiota are associated with risk for age-related macular degenerationR21EY028209 · NEI · ADA FORSYTH INSTITUTE, INC. · PI CHIU, CHUNG-JUNG · 2018 to 2019
$547k
NEI NIH HHS R01 EY021826NEI NIH HHS R21 EY028209
6 · The paper itself

Abstract

SIGNIFICANCE STATEMENT: While our oral microbiome may impact eye health, nutritional factors could play a modulatory role in mitigating the associated risk.

Indexed as

age-related macular degenerationepidemiologyluteinmicrobiomemicrobiotaNational Health and Nutrition Examination Survey (NHANES)periodontitisPorphyromonas gingivalisretinarisk factorszeaxanthin

Identifiers

PMID40386394
PMCPMC12083656

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.