Evidence map›Paper›PMID 40386408›Full record

ArticleResearch square2025

Genetic Profiling of Synchronous Pituitary Corticotroph Adenomas.

Dongyun Zhang, Karen Tsai, Cristian Santana, Keanu Javaherian, Matthew Lee, Marvin Bergsneider, Kim Won, Marilene B Wang, Harry V Vinters, Weihong Yan and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Dongyun ZhangUniversity of California.
Karen TsaiUniversity of California.
Cristian SantanaUniversity of California.
Keanu JavaherianUniversity of California.
Matthew LeeUniversity of California.
Marvin BergsneiderUniversity of California.
Kim WonUniversity of California.
Marilene B WangUniversity of California.
Harry V VintersUniversity of California.
Weihong YanUniversity of California.
Anthony P HeaneyUniversity of California.

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discoveryR01CA251930 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEANEY, ANTHONY P · 2021 to 2025
$1.8M
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA251930
6 · The paper itself

Abstract

Purpose: Double or multiple pituitary adenomas account for only 1.6-3.3% of all corticotroph tumors. We sought to better understand the underlying molecular pathogenesis of 2 distinct corticotroph adenomas that were encountered in a 43-year-old female. Methods: Two distinct histopathologically confirmed corticotroph adenomas were submitted for whole exome sequencing (WES) together with blood sample. The functional effects of identified pathogenic variants on murine corticotroph tumor pro-opio-melanocortin ( Results: WES demonstrated a loss-of-function variant in the G-protein coupled receptor 162 [ Conclusion: We hypothesize that the germline

Indexed as

Cushing diseaseCYP21A2GPR162single cell RNAseqUSP8whole exosome sequencing

Identifiers

PMID40386408
PMCPMC12083677

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.