ArticleFrontiers in bioengineering and biotechnology2025
Supramolecular nanofibers of natural asiaticoside for self-supporting gelation and enhanced transdermal delivery.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1-Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Preparation of postbioYDFF-3 loaded absorbent pad and its application in fresh-keeping of refrigeration grass carp slices.Food chemistry: X · 2025Article
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Authors and funding
11 authors.
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Abstract
Objectives: The study aimed to develop a supramolecular hydrogel of asiaticoside (AS) via self-assembly and evaluate its potential for enhanced transdermal delivery. Materials and Methods: AS was dissolved in dimethyl sulfoxide (DMSO) and dispersed into a glycerol-water mixture (3:7 v/v) via ultrasonication to induce gelation. The critical gelation concentration (CGC) was determined through macroscopic and microscopic evaluation. Morphological analysis was performed using various microscopy techniques. Physicochemical properties were assessed using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier-transform infrared (FTIR) spectroscopy, and UV-VIS spectroscopy. Molecular dynamics (MD) simulations with general AMBER force field (GAFF) parameters were used to analyze assembly dynamics. Rheological behavior and transdermal performance were tested using a rheometer and Franz diffusion cells, respectively. Results: The hydrogel formed at a CGC of 0.5% w/v, exhibiting pH-responsive gelation and a nanofibrous architecture. MD simulations revealed hydrogen bonding and π-π stacking as the dominant drivers of assembly, supported by FTIR peak shifts. The hydrogel demonstrated shear-thinning behavior (G' > G″) and thermal stability below 70°C. Compared to the AS suspension, the hydrogel enhanced transdermal flux by 1.73-fold and skin retention by 2.04-fold, attributed to supersaturated drug molecules and sustained release from the nanofiber network. Conclusion: This work pioneers the use of AS as a natural supramolecular gelator, addressing its bioavailability challenges through nanostructured self-assembly. The hydrogel's dual functionality (pH-responsive gelation and enhanced permeation) offers a sustainable platform for the transdermal delivery of hydrophobic phytochemicals, bridging phytochemistry and nanobiotechnology. This strategy expands the application of plant-derived saponins in advanced drug delivery systems.
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