Platelet-Rich Plasma in Arthroscopic Repair of Full-Thickness Rotator Cuff Tears: A Cross-sectional Analysis of Overlapping Meta-analyses.

Background: Platelet-rich plasma (PRP) has been utilized as adjunctive therapy in arthroscopic rotator cuff repair. However, there is currently limited research available on the efficacy of PRP in arthroscopic repair of full-thickness rotator cuff tears. Purpose: This study aimed to perform a cross-sectional analysis of overlapping meta-analyses comparing the clinical efficacy of arthroscopic repair of full-thickness rotator cuff tears with and without PRP to assist clinicians in assessing the most reliable evidence and formulating treatment recommendations accordingly. Study Design: Systematic review; Level of evidence, 2. Methods: Under PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, comprehensive searches of meta-analyses were performed in the PubMed, Embase, and Cochrane Library databases until June 1, 2024, and found 63 studies. The methodological quality of the included studies was evaluated using the Assessment of Multiple Systematic Reviews (AMSTAR) and Oxford Centre for Evidence-Based Medicine Levels of Evidence instruments. Data extraction from the included meta-analyses was independently performed by 2 reviewers. The Jadad decision algorithm was employed to identify meta-analyses with the most robust evidence. Results: This study included 5 meta-analyses. These meta-analyses had AMSTAR scores ranging from 7 to 9, with a mean of 8. The most reliable evidence, assessed by the Jadad algorithm, included 8 randomized controlled trials and involved 566 patients. It showed that the short-term (≤12 months after surgery) retear rate and visual analog scale score were significantly lower in those with PRP than in those without PRP. The short-term Constant score, short-term University of California, Los Angeles (UCLA) activity score, and long-term (>12 months after surgery) UCLA score were significantly higher in the PRP group, especially in single-row fixation. Conclusion: Our study demonstrates that the most reliable evidence suggests that PRP injections can be recommended as adjunctive therapy in single-row repair for enhanced short-term outcomes. Further high-quality randomized controlled trials are imperative to increase the strength of evidence.