Observational studyAnnals of clinical and translational neurology2025
The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type.
Observational study in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Bi- and Mono-Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy.Annals of clinical and translational neurology · 2026Article
- Bioenergetic failure in diabetic peripheral neuropathy: from glucotoxicity to multidimensional metabolic imbalance.Journal of neurology · 2026Review
- Plasma Lipoproteins as Key Regulators in Neuropathic Pain: A Comprehensive Review of Mechanisms and Clinical Potential.Pain and therapy · 2026Review
- Predictors of Peripheral Neuropathy in Metabolic Disease: A Multivariable Analysis Incorporating the Toronto Clinical Scoring System and Sudomotor Assessment.Medicina (Kaunas, Lithuania) · 2026Article
- A neuron-astrocyte signaling axis in the ACC sustains diabetic neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes.European journal of neurology · 2025Article
- Commentary on "The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type".Annals of clinical and translational neurology · 2025Article
- Reply to: Commentary on "The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type".Annals of clinical and translational neurology · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveDetermine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy.
methodsThe Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes (DPN) and non-diabetic peripheral neuropathy (cryptogenic sensory polyneuropathy and prediabetes) using cross-sectional observational data. Associations between diabetes or MetS burden and pain presence (yes/no), neuropathy severity (Total Neuropathy Score reduced), and fiber type involvement (pinprick, vibration, and proprioception examination-small, large, mixed) using logistic, linear, and multinomial regression models were determined.
resultsA total of 1112 participants were included (265 DPN, 847 non-diabetic peripheral neuropathy [NDPN]). Compared to NDPN, DPN participants were more likely to have pain, higher neuropathy severity, and mixed fiber involvement. In adjusted models, diabetes was associated with pain (odds ratio [OR] 1.85, CI: 1.15-3.03) and severity (point estimate [PE] 0.84, CI: 0.27-1.42), but not fiber type involvement. As the MetS burden increased, pain, neuropathy severity, and mixed fiber type involvement increased (p < 0.05 for trend). In adjusted models, MetS burden was associated with pain (OR 1.23, CI: 1.06-1.41) but not severity or fiber type involvement.
interpretationParticipants with DPN were more likely to have pain, greater neuropathy severity, and possibly more mixed fiber involvement than those with NDPN. Similarly, increasing MetS burden also led to more painful neuropathy and possibly more severe neuropathy with more mixed fiber involvement.
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