ArticleEpilepsia2025
Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases.medRxiv : the preprint server for health sciences · 2026Article
- An Implantable Device that Converses with Patients and Learns to Co-Manage Epilepsy.medRxiv : the preprint server for health sciences · 2026Article
- Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.Epilepsia · 2025Article
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Authors and funding
17 authors.
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Abstract
objectiveMesial temporal lobe epilepsy is a common localization of drug-resistant epilepsy in adults. Patients often undergo intracranial electroencephalographic monitoring to confirm localization and determine candidacy for focal ablation or resection. Clinicians primarily base surgical decision-making on seizure onset patterns, with imaging abnormalities and information from interictal epileptiform discharge (spikes) used as ancillary data. How the morphology and timing of spikes within multielectrode sequences may inform surgical planning is unknown, in part due to the lack of measurement methods for large datasets. We hypothesized that patients with mesial temporal lobe epilepsy have a distinct mesial-to-lateral spike gradient that differentiates them from other epilepsy localizations.
methodsIn a multicenter study at the University of Pennsylvania and the Medical University of South Carolina, we analyzed the timing and morphology of spikes and seizure high-frequency energy ratio in 75 patients with drug-resistant epilepsy. We compared these features across patients with mesial temporal lobe epilepsy, temporal neocortical epilepsy, and other localizations.
resultsA logistic regression model combining all features predicted a clinical localization of mesial temporal lobe epilepsy in unseen patients with an area under the receiver operating characteristic curve of .82 (compared to an area under the receiver operating characteristic curve of .70 for seizure-only features, DeLong test p = .08) and an average precision of .84. Spike rate was the most important feature in the combined model. SIGNIFICANCE: These findings advance surgical planning by demonstrating that quantitative spike analysis can effectively supplement seizure data in localizing mesial temporal lobe epilepsy. This approach could reduce reliance on prolonged seizure monitoring, potentially decreasing patient risk and hospitalization costs while improving surgical targeting. Our results support incorporating automated spike analysis into standard clinical workflows for epilepsy surgery evaluation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.