Evidence map›Paper›PMID 40387448›Full record

ArticleActa physiologica (Oxford, England)2025

Comparison of Phasic Store-Operated Calcium Entry in Rat Slow- and Fast-Twitch Muscle Fibers.

Elena Lilliu, Rocky Choi, Karlheinz Hilber, Bradley Launikonis, Xaver Koenig

Abstract readComparative Study
In one paragraph

Article in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elena LilliuCenter for Physiology and Pharmacology, Medical University of Vienna, Wien, Austria.ORCID https://orcid.org/0009-0006-6346-4584
Rocky ChoiSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Karlheinz HilberCenter for Physiology and Pharmacology, Medical University of Vienna, Wien, Austria.
Bradley LaunikonisSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0003-0700-4867
Xaver KoenigCenter for Physiology and Pharmacology, Medical University of Vienna, Wien, Austria.ORCID https://orcid.org/0000-0002-2423-4966

Funding

Austrian Science FundÖsterreichischen Akademie der Wissenschaften
6 · The paper itself

Abstract

aimThis study investigates the activation and regulation of phasic store-operated calcium entry (pSOCE) in fast- and slow-twitch skeletal muscle fibers. Specifically, we aimed to enhance the sensitivity of pSOCE detection in slow-twitch fibers by optimizing ionic conditions and to compare the physiological relevance of pSOCE between fiber types.

methodsWe employed mechanically skinned fast-twitch extensor digitorum longus (EDL) muscle fibers loaded with spectrally distinct Ca

resultsSkinned soleus fibers exhibited ~8-fold lower Ca

conclusionThese findings reveal a novel, fiber-type-specific difference in pSOCE regulation. When compared to EDL fibers, soleus fibers exhibited a higher sensitivity to SOCE activation despite releasing less Ca

Indexed as

CalciumCalcium SignalingMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchAction PotentialsAnimalsMaleRatsSarcoplasmic ReticulumCalciumcalciumEC‐couplingskeletal muscleslow‐twitch musclestore‐operated calcium entry

Identifiers

PMID40387448
PMCPMC12087525

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.