Evidence map›Paper›PMID 40388406›Full record

ArticleExperimental physiology2025

Chronic intermittent hypoxia-mediated cognitive dysfunction in ovariectomized rats.

Emily C Cheung, Joan B Escobar, Bridget R Alber, Caitlin Ribeiro, Ishan Abdullah, Grant Kowalik, Jeannette Rodriguez, Grey Harral, Makeda Melkie, Aman Gill and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emily C CheungDepartment of Pharmacology and Physiology, George Washington University, Washington, District of Columbia, USA.
Joan B EscobarDepartment of Pharmacology and Physiology, George Washington University, Washington, District of Columbia, USA.
Bridget R AlberDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
Caitlin RibeiroDepartment of Pharmacology and Physiology, George Washington University, Washington, District of Columbia, USA.
Ishan AbdullahDepartment of Pharmacology and Physiology, George Washington University, Washington, District of Columbia, USA.
Grant KowalikDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
Jeannette RodriguezDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
Grey HarralDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
Makeda MelkieDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
Aman GillDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
John T KetzenbergerDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.
John BetheaDepartment of Anatomy and Cell Biology, George Washington University, Washington, District of Columbia, USA.
Vsevolod Y PolotskyDepartment of Anesthesiology and Critical Care Medicine, George Washington University, Washington, District of Columbia, USA.
Vivek JainDepartment of Medicine, George Washington University, Washington, District of Columbia, USA.
Kathryn SchunkeDepartment of Cell & Molecular Biology, University of Hawaii, Honolulu, Hawai'i, USA.
Matthew W KayDepartment of Biomedical Engineering, George Washington University, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0003-2756-5055
David MendelowitzDepartment of Pharmacology and Physiology, George Washington University, Washington, District of Columbia, USA.

Funding

Hypothalamic neuron activation to blunt myocardial remodeling during chronic sleep apneaR01HL146169 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI KAY, MATTHEW W. · 2019 to 2022
$2.6M
Collin's Fellowship and Metro Washington Chapter Achievement Rewards for College Scientists (ARCS)HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146169NHLBI NIH HHS R01 HL146169
6 · The paper itself

Abstract

Obstructive sleep apnoea (OSA) is a prevalent cardiorespiratory disorder associated with significant neurocognitive consequences. Despite the higher prevalence of OSA in men, there is a strong association between OSA and Alzheimer's disease (AD), which disproportionately affects women. This study aimed to investigate the impact of chronic intermittent hypoxia (CIH), a hallmark of OSA, on cognitive function and AD markers in ovariectomized, female rats. At 8 weeks of age, 16 Sprague-Dawley rats underwent ovariectomy and were exposed to CIH for 26 weeks. Cognitive function was assessed using the Morris water maze, revealing significant deficits in spatial learning (P < 0.0001) and memory (P = 0.008) in CIH-exposed rats, compared to controls. Analysis of hippocampal tissue showed increased total tau protein (P = 0.0078), indicative of AD pathology. Additionally, CIH-exposed rats exhibited respiratory dysfunction characterized by increased frequency of apnoeas (P = 0.0328). These findings provide preclinical evidence of the association between OSA, cognitive decline and AD pathology in females, emphasizing the importance of sex-specific research in understanding and addressing these pathophysiological interconnections.

Indexed as

Cognitive DysfunctionHypoxiaAlzheimer DiseaseAnimalsCognitionFemaleHippocampusMaze LearningOvariectomyRatsRats, Sprague-DawleySleep Apnea, Obstructivetau Proteinstau ProteinsAlzheimer's diseaseMorris water mazeobstructive sleep apnoeaovariectomyplethysmographyrespiration

Identifiers

PMID40388406
PMCPMC12314638

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.