Evidence map›Paper›PMID 40389844›Full record

ArticleBMC plant biology2025

Multi-omics analysis of the mechanisms of abundant theacrine and EGCG3"Me in tea (Camellia sinensis).

Yanyu Zhu, Mengya Gu, Wentao Yu, Longhua Liao, Shuilian Gao, Shuyan Wang, Hongzheng Lin, Wenjing Gui, Youliang Zhou, Zhiming Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanyu ZhuCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.
Mengya GuCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.
Wentao YuFujian Key Laboratory for Technology Research of Inspection and Quarantine, Technology Center of Fuzhou Customs District PR China, Fuzhou, 350001, Fujian, China. wtyu@foxmail.com.
Longhua LiaoFujian Yongganhua Tea Industry Co., Ltd, Fuzhou, 350011, Fujian, China.
Shuilian GaoCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.
Shuyan WangCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.
Hongzheng LinCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.
Wenjing GuiCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.
Youliang ZhouFujian Guoxin Green Valley Agricultural Development Co., Ltd, Anxi, 362400, Fujian, China.
Zhiming ChenAnxi Tea Industry Development Center, Anxi, 362400, Fujian, China.
Jingde ZengAnxi Tea Industry Development Center, Anxi, 362400, Fujian, China.
Naixing YeCollege of Horticulture-Key Laboratory of Tea Science at Universities in Fujian, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China. ynxtea@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theacrine and epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) are notable secondary metabolites in tea (Camellia sinensis), celebrated for their unique flavors and significant health effects. Theacrine has a mild effect on nerve stimulation, while EGCG3"Me exhibits better stability, higher oral bioavailability and stronger biological activity. However, tea plant varieties naturally rich in both theacrine and EGCG3"Me are rare. This study unveils a unique tea variety 'Anxi kucha', which is abundant in both theacrine and EGCG3"Me. Through integrated transcriptome-proteome-metabolome analysis, SAMS3, APRT1, IMPDH, and TCS1 were identified as critical enzymes for theacrine synthesis; while CHI1, CHI2, FLS2 and LAR1 were key for EGCG3"Me synthesis. Additionally, transcription factor analysis revealed that MYB4 and bHLH74 were positively correlated with the contents of theacrine and EGCG3"Me. This study provides valuable materials for further exploring theacrine and EGCG3"Me in tea plants, and establishes a theoretical basis for their biosynthesis.

Indexed as

Camellia sinensisCatechinGallic AcidMetabolomeMultiomicsPlant ProteinsTranscriptomeCatechinepigallocatechin-3-O-(3''-O-methyl)-gallateGallic AcidPlant ProteinsAnxi KuchaCamellia sinensisepigallocatechin-3-O-(3-O-methyl) gallateMetabolic pathwaysProteomics; transcriptomicsTheacrine

Identifiers

PMID40389844
PMCPMC12087082

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.