ArticleBMC ophthalmology2025
Pregnancy-induced ocular changes: impacts on intraocular pressure, the cornea, and the anterior chamber.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pregnancy and Dry Eye Syndrome: A Review for Clinical Practice.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to comprehensively evaluate the trimester-specific effects of pregnancy on intraocular pressure, corneal biomechanics, anterior segment anatomy, and endothelial cell morphology.
methodsThis prospective cross-sectional study included 90 healthy pregnant women (30 per trimester) and 30 age-matched non-pregnant controls. Comprehensive ophthalmological assessments were performed, including IOP measurement using a non-contact tonometer, corneal structure evaluation with Pentacam Scheimpflug imaging, and endothelial cell analysis using a specular microscope.
resultsA significant decrease in IOP was observed in the third trimester compared to the control group (p = 0.016), although no significant difference was noted in the first and second trimesters (p > 0.05). Corneal endothelial analysis revealed a significant decrease in hexagonal cell percentage (HEX) values during the first trimester (p = 0.007). Correlation analysis demonstrated a strong positive relationship between central corneal thickness (CCT) and corneal volume (r = 0.817, p < 0.001) and a moderate positive correlation between CCT and IOP (r = 0.263, p = 0.004). Axial length was strongly negatively correlated with both flat keratometry (r=-0.562, p < 0.001) and steep keratometry (r=-0.538, p < 0.001), and strongly positively correlated with anterior chamber volume and anterior chamber depth (r = 0.380, p < 0.001 and r = 0.384, p < 0.001, respectively). A moderate positive correlation was also identified between gestational trimester and HEX (r = 0.257, p = 0.005).
conclusionsPregnancy induces temporary but significant ophthalmological changes, particularly a decrease in IOP in the third trimester and a decrease in HEX in the first. These findings highlight the importance of monitoring ocular health during pregnancy to detect potential risks early and ensure timely intervention.
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Registered trials
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