ArticleCureus2025
A Comparative Study on Genotoxic and Oxidative DNA Damage in Oral Epithelial Cells of COVID-19 Suspected Patients.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Analysis of Cytological Markers of Cellular Senescence in High-Risk Cardiovascular Patients After COVID-19.BioMed research international · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction The SARS-CoV-2 virus causes COVID-19 by chiefly infecting the nasal and oral mucosal cavities, where its spike proteins bind to angiotensin-converting enzyme II (ACE2) receptors on epithelial cells. This study aimed to assess SARS-CoV-2-related genotoxicity in buccal mucosal cells through micronuclei counts and 8-Oxo-2'-deoxyguanosine (8-OHdG) expression. Methods This cross-sectional study was conducted in 86 COVID-19 suspected patients aged 18-45 years attending an outpatient screening area for reverse transcription polymerase chain reaction (RT-PCR) SARS-CoV-2 testing between December 2023 and February 2024. Salivary swabs were obtained and smeared on glass slides for each patient. These slides were stained to study and compare cellular toxicity by Papanicolaou (Pap) staining and oxidative DNA damage expression by immunohistochemistry. The categorical and continuous variables were assessed using the independent t-test and ANOVA. A p-value of less than 0.05 was considered statistically significant. Results The number of micronucleated cells, total micronuclei, neutrophil, lymphocyte and inflammatory cell count in COVID-19 RT-PCR positive patients were 11.32 ± 7.00, 17.32± 12.53, 1.93 ± 1.17, 3.98 ± 2.55 and 5.90 ± 3.15 respectively which is higher than COVID-19 RT-PCR negative individuals 6.09± 3.83, 9.04± 5.82, 0.18± 0.49, 2.13± 0.84 and 2.31±1.01 respectively. Moreover, buccal cells showed increased oxidative DNA damage with intense staining for 8-OHdG in COVID-19-positive patients. The epithelial-to-inflammatory cell ratio was very low in COVID-19-positive buccal smear patients. Conclusion This study concludes that SARS-CoV-2 has a genotoxic effect by increasing the micronuclei count and has oxidative DNA damage by increasing the 8-OHdG expression in the exfoliated buccal cells.
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