Evidence map›Paper›PMID 40391486›Full record

ArticleRegenerative medicine2025

Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series.

Dulic Oliver, Abazovic Dzihan, Obradovic Mirko, Vranjes Miodrag, Lalic Ivica, Ninkovic Srdjan, Rasovic Predrag, Bjelobrk Mile, Baljak Branko, Milinkov Milan and 2 more

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In one paragraph

Article in Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dulic OliverUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Abazovic DzihanRenova Hospital, Belgrade, Serbia.
Obradovic MirkoUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Vranjes MiodragUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Lalic IvicaFaculty Of Pharmacy, University Business Academy in Novi Sad, Novi Sad, Serbia.
Ninkovic SrdjanUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Rasovic PredragUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Bjelobrk MileUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Baljak BrankoUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Milinkov MilanUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Tosic MilanUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Sarac SrdjanUniversity of Novi Sad, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the effectiveness of a bioregenerative scaffold created from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin in treating complicated non-unions of the supracondylar femur, humeral shaft, and radius and ulna. METHODS & MATERIALS: Three patients with non-unions resulting from multiple surgical failures underwent bone stabilization along with the application of a novel bioregenerative scaffold. X-rays and subjective assessments were collected prior to surgery and at 6- and 12-months post-surgery.

resultsAll non-unions demonstrated healing with adequate callus formation, as confirmed by radiological assessments. By 12 months, all patients were able to resume full weight-bearing activities or regain full range of motion and physical strength without pain. Statistical analysis revealed improvements across all assessment scales compared to pre-surgical values.

conclusionThis approach offers a viable option for treating complex long bone non-unions after multiple surgical interventions.

Indexed as

Bone TransplantationCancellous BoneFemurFibrinFractures, UnunitedHumerusPlatelet-Rich PlasmaTissue ScaffoldsHumansTransplantation, AutologousFibrinBioregenerative orthopedicsbioregenerative scaffoldbone marrow aspirate concentratebone non-unionplatelet rich plasma

Identifiers

PMID40391486
PMCPMC12118442

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.