Evidence map›Paper›PMID 40393055›Full record

ArticleACS chemical neuroscience2025

Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic Stability: An In Vitro, In Vivo, and In Silico Study.

Delmis E Hernandez, Dan Luo, Thomas E Prisinzano, S Stevens Negus, Nima Nassehi, Dana E Selley, Pranav Shah, Rintaro Kato, Xin Xu, Carmine Talarico and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Delmis E HernandezDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States.
Dan LuoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, Kentucky 40536, United States.
Thomas E PrisinzanoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, Kentucky 40536, United States.ORCID 0000-0002-0649-8052
S Stevens NegusDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, 1112 East Clay Street, Richmond, Virginia 23298, United States.
Nima NassehiDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, 1112 East Clay Street, Richmond, Virginia 23298, United States.
Dana E SelleyDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, 1112 East Clay Street, Richmond, Virginia 23298, United States.
Pranav ShahDepartment of Health and Human Services, Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, National Institutes of Health, 9808 Medical Center Drive, Rockville, Maryland 20850, United States.
Rintaro KatoDepartment of Health and Human Services, Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, National Institutes of Health, 9808 Medical Center Drive, Rockville, Maryland 20850, United States.
Xin XuDepartment of Health and Human Services, Drug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, National Institutes of Health, 9808 Medical Center Drive, Rockville, Maryland 20850, United States.
Carmine TalaricoEXSCALATE-Dompé Farmaceutici SpA, Via Tommaso De Amicis 95, 80131 Napoli, Italy.
Davide GrazianiEXSCALATE-Dompé Farmaceutici SpA, Via Tommaso De Amicis 95, 80131 Napoli, Italy.
Andrea R BeccariEXSCALATE-Dompé Farmaceutici SpA, Via Tommaso De Amicis 95, 80131 Napoli, Italy.
Arthur E JacobsonDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States.
Kenner C RiceDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States.
Agnieszka SulimaDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States.ORCID 0000-0002-8849-9736

Funding

Pharmacokinetics and Drug MetabolismZIATR000369 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI XU, XIN · 2018 to 2025
$27.3M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
Development of Agents for Synthetic Opioid OverdoseU01DA051377 · NIDA · UNIVERSITY OF KENTUCKY · PI PRISINZANO, THOMAS EDWARD · 2021 to 2023
$1.4M
Intramural NIH HHS ZIA TR000369NIDA NIH HHS P30 DA033934NIDA NIH HHS U01 DA051377
6 · The paper itself

Abstract

Replacement of the phenolic hydroxy in 3-((1

Indexed as

Analgesics, OpioidMorpholinesReceptors, Opioid, muAnimalsComputer SimulationCyclic AMPDrug Partial AgonismHumansMaleMiceMicrosomes, LiverMolecular Docking SimulationStructure-Activity RelationshipAnalgesics, OpioidCyclic AMPMorpholinesReceptors, Opioid, muagonistsantagonistsbioisosteresmu opioid receptor (MOR)opioid use disorder (OUD)

Identifiers

PMID40393055
PMCPMC12136991

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.