ReviewRNA (New York, N.Y.)2025
Implications for OLE RNA as a natural integral membrane RNA.
Review in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Molecular insights into dynamic RNA quaternary assemblies.RNA biology · 2026Review
- Membrane-Spanning Nanopores Formed from Nucleic Acids.Chemical reviews · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ornate, large, extremophilic (OLE) RNAs, found in many Gram-positive bacterial species, represent an unusual class of noncoding RNAs, which form a large ribonucleoprotein complex that localizes to cell membranes. Although the precise biochemical functions of OLE RNAs remain to be discovered, several lines of evidence suggest that they participate in forming particles that function as the master regulators of their bacterial hosts. Thus, OLE RNA might be a molecular relic of RNA World organisms that contributed to cellular stress responses long before the evolutionary emergence of proteins. Recent reports of partial 3D structures strongly suggest that OLE RNAs form a molecular dimer whose complex structure spans the phospholipid bilayer of membranes. The implications of these findings on the functions of OLE RNA and on the capabilities of RNA polymers more broadly are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.