Evidence map›Paper›PMID 40394363›Full record

ArticleRice (New York, N.Y.)2025

Large Grain 2, an NHL Domain-Containing Protein, Interacts with FUWA and Regulates Plant Architecture and Grain Size Through the Brassinosteroid Signaling Pathway in Rice.

Zhengyan Xu, Jierui Zeng, Xiaorong Zhou, Yang Liu, Feifan Chen, Haitang Liu, Xiao Peng, Zhengqi Han, Feihong Hou, Hao Wang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rice (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Zhengyan Xu *State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Jierui Zeng *State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Xiaorong Zhou *State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Yang LiuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Feifan ChenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Haitang LiuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Xiao PengState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Zhengqi HanState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Feihong HouState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Hao WangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Weilan ChenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Bin TuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Ting LiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Jiawei XiongState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Zhaohui ZhongState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Yuping WangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Bingtian MaState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Peng QinState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Shigui LiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China. lishigui@sicau.edu.cn.
Hua YuanState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China. yuanhua14536@sicau.edu.cn.

Funding

Key Research and Development Projects of Sichuan 2021YFYZ0016National Key Research and Development Program of China 2022YFD1200104National Natural Science Foundation of China 32272063National Natural Science Foundation of China 32325038Sichuan Science and Technology Program 2025NSFTD0024the Open Project Program of the State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China SKL-ZD202207the Open Project Program of the State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China SKL-ZY202212
6 · The paper itself

Abstract

Plant architecture and grain size are critical traits for rice breeding. Brassinosteroid (BR), a class of plant hormones, regulates these traits by modulating cell elongation, division, and differentiation. Therefore, exploring BR-related genes to leverage their pleiotropic effects is crucial for crop improvement. We identify a novel gene, Large Grain 2 (LG2), which encodes a Golgi-localized protein containing an NHL domain. This gene plays a crucial role in regulating both plant architecture and grain size in rice. Mechanistically, FUWA, a paralog of LG2, directly interacts with LG2 and enhances its protein stability. Furthermore, our findings indicate that LG2 is involved in BR signaling. Collectively, these results suggest that the LG2-FUWA module synergistically regulate plant architecture and grain size through the BR pathway in rice. Our study provides new insights into the function of NHL domain-containing proteins in plants and introduces a novel BR component for crop improvement. The LG2-FUWA module regulates plant architecture and grain size through the BR pathway in rice.

Indexed as

BR signalingGrain sizeNHL domainPlant architectureRice

Identifiers

PMID40394363
PMCPMC12092888

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.