Evidence map›Paper›PMID 40394609›Full record

ArticleReproductive health2025

Changes in the global burden of polycystic ovary syndrome from 1990 to 2021.

Tong Lin, Bingqin Xie, Juan Yang, Jinbang Xu, Fa Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tong Lin *Department of Traditional Chinese Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China.
Bingqin Xie *Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Juan YangDepartment of Traditional Chinese Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China.
Jinbang XuDepartment of Traditional Chinese Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China. xujinbang@fjmu.edu.cn.
Fa ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China. chenfa@fjmu.edu.cn.

Funding

Fujian Provincial Health Technology Project 2023ZQNZD01010013Fujian Provincial Natural Science Foundation of China 2022QNA054Joint Funds for the innovation of Science and Technology, Fujian province 2020Y94020265National Nature Science Foundation of China 82074542
6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is a chronic, multifaceted condition influenced by epigenetic and environmental factors that is responsible for a significant proportion of anovulatory infertility cases. Here, we analyzed the global, regional, and national burdens of PCOS from 1990 to 2021 using data from the Global Burden of Disease 2021 (GBD 2021).

methodsIncidence, prevalence, and Disability-Adjusted Life Years (DALYs) data relevant to PCOS from 204 countries and 21 territories from 1990 to 2021 were obtained from the GBD 2021 study. Here, we considered age-standardized rates (per 100,000 individuals) with 95% uncertainty intervals (95% UIs) obtained from the aforementioned research and presented trends based on age and Socio-demographic Index (SDI) parameters.

resultsIn 2021, the global age-standardized incidence and prevalence rates of PCOS were 30.7 per 100,000 and 867.7 per 100,000, respectively, representing an increase of 26.77% and 28.21% since 1990. Additionally, age-standardized disability-adjusted life years stood at 7.6 per 100,000 globally in 2021, marking a 27.58% increase from 1990. Age-standardized prevalence of PCOS varied across countries, ranging from 93.1 to 3978.9 cases per 100,000 women, with Italy (3978.9), Japan (3104.7), and New Zealand (2789.7) having the highest rates. Notably, PCOS prevalence was noted to peak globally among females 15-19 years of age. Regions with a high SDI exhibited the highest age-standardized incidence (70.2), prevalence (1720.7), and DALY (15.2) rates of PCOS. Furthermore, a nonlinear correlation between PCOS burden and SDI was noted, with prevalence rates peaking around an SDI of approximately 0.9.

conclusionOur findings highlight the growing global impact of PCOS and underscore the need for concerted efforts to attenuate the increasing global prevalence of this condition. Significantly divergent PCOS disease burdens were observed across different age groups and SDI regions, with high SDI regions bearing heavier burdens. The increased disease burden among younger age groups and regional disparities underscore urgency for targeted intervention and formulation of policies to effectively address this public health issue.

Indexed as

Global Burden of DiseasePolycystic Ovary SyndromeAdolescentAdultCost of IllnessDisability-Adjusted Life YearsFemaleGlobal HealthHumansIncidenceMiddle AgedPrevalenceQuality-Adjusted Life YearsYoung AdultDisability-adjusted life yearsGlobal burden of diseasePolycystic ovary syndromeSocio-demographic index

Identifiers

PMID40394609
PMCPMC12090547

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.