ArticleEuropean journal of medical research2025
Sex-specific association between serum α-klotho levels and sleep disturbances in the elderly: a cross-sectional study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundSleep disturbances (SD) exhibit a high prevalence among older adults and exert considerable influence on cardiovascular health, quality of life, and other facets of well-being. α-Klotho, an anti-aging factor that diminishes with advancing age, has been implicated in a multitude of age-related conditions. However, the relationship between SD and α-klotho levels in the elderly remains inadequately investigated, and potential sex-specific differences in this association warrant further exploration.
methodsThis study utilized data from the National Health and Nutrition Examination Survey (NHANES) to initially investigate the association between α-klotho levels and SD, with analyses conducted separately for both sexes. In addition, the relationship was further delineated using restricted cubic spline (RCS) curves.
resultsA total of 5,957 elderly adults participated in this study, revealing a prevalence of SD at 29.5%. Notably, females exhibited a higher prevalence of SD compared to men (33.6% for females vs. 25.3% for males). After adjusting for covariates, higher α-klotho levels were hypothesized to be associated with a decreased incidence of SD. Differences also existed between sexes, as demonstrated by a significant correlation between serum α-klotho and SD in females, but not in males. Results from the RCS analysis indicated a negative and nonlinear relationship between α-klotho levels and SD, consistent across both sexes and the general population.
conclusionsThe findings of the current study revealed a negative association between α-klotho levels and the development of SD in the elderly population, with notable sex-specific differences.
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