ArticleFrontiers in medicine2025
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Previous studies have demonstrated the significant efficacy of Methods: Data on COPD, along with the active ingredients and target genes of Zijinniu and Tiesaozhou, were utilized. By integrating the results of differential expression analysis and the target genes of these two plants, candidate genes were identified. Key genes were then confirmed through gene expression analysis in the GSE124180 and GSE42057 datasets. A nomogram was constructed based on these genes to assess COPD risk, followed by validation. Additionally, functional analysis, immune factor profiling, molecular docking, and reverse transcription-polymerase chain reaction (RT-qPCR) were performed. Results: HK2 and PTAFR emerged as critical genes for COPD treatment, exhibiting significantly elevated expression in COPD samples. RT-qPCR confirmed the significantly higher expression of HK2 ( Conclusion: HK2 and PTAFR were identified as crucial genes in COPD, providing a solid theoretical foundation for future treatment strategies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.