Evidence map›Paper›PMID 40395348›Full record

ReviewSmall science2025

Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.

Zaiyong Zheng, Shuang Zhu, Xiaobo Wang, Haoran Wu, Min Fu, Houxiang Hu, Zhanjun Gu, Chunxiang Zhang

Abstract readReview
In one paragraph

Review in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zaiyong ZhengDepartment of Cardiology Key Laboratory of Medical Electrophysiology Ministry of Education, Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education, The Affiliated Hospital of Southwest Medical University Southwest Medical University Luzhou 646000 China.ORCID https://orcid.org/0000-0003-4731-1829
Shuang ZhuCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Beijing 100049 China.ORCID https://orcid.org/0000-0002-3962-0587
Xiaobo WangAcademician Workstation and Department of Cardiology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China.
Haoran WuDepartment of Cardiology Key Laboratory of Medical Electrophysiology Ministry of Education, Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education, The Affiliated Hospital of Southwest Medical University Southwest Medical University Luzhou 646000 China.
Min FuDepartment of Cardiology Key Laboratory of Medical Electrophysiology Ministry of Education, Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education, The Affiliated Hospital of Southwest Medical University Southwest Medical University Luzhou 646000 China.ORCID https://orcid.org/0009-0004-4009-8724
Houxiang HuAcademician Workstation and Department of Cardiology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China.ORCID https://orcid.org/0000-0002-6520-2477
Zhanjun GuCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Beijing 100049 China.ORCID https://orcid.org/0000-0003-3717-2423
Chunxiang ZhangDepartment of Cardiology Key Laboratory of Medical Electrophysiology Ministry of Education, Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education, The Affiliated Hospital of Southwest Medical University Southwest Medical University Luzhou 646000 China.ORCID https://orcid.org/0000-0001-8303-6495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, the circulatory system stands out as particularly vulnerable, drawing additional attention to its cardiac toxicity. To address the cardiovascular nanotoxicity and further promote the safe use of nanotechnology, a comprehensive review of the cardiotoxicity induced by nanomaterials is provided. The review begins by identifying the current research trends and hotspots in this field via a bibliometric analysis. Subsequently, based on the objectively obtained research hotspots, the mechanism of cardiovascular nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, and cell death, is reviewed and discussed. Finally, current strategies for the mitigation of nanotoxicity are also proposed. The objective of this review is to assist readers in understanding the mechanism of cardiotoxicity induced by nanomaterials and to facilitate their safe application for human health.

Indexed as

bibliometric analysescardiovascular healthnanomaterialsnanotoxicities

Identifiers

PMID40395348
PMCPMC12087784

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.