Evidence map›Paper›PMID 40395492›Full record

ReviewMechanobiology in medicine2024

Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration.

Xiao Lin, Hua Yang, Yi Xia, Kang Wu, Fengcheng Chu, Huan Zhou, Huajian Gao, Lei Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mechanobiology in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  16. Harnessing mechanobiology to enhance cell therapy.Mechanobiology in medicine · 2024
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao LinOrthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, China.
Hua YangSchool of Mechanical Engineering, Hebei University of Technology, Tianjin, China.
Yi XiaCenter for Health Sciences and Engineering (CHSE), Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, China.
Kang WuOrthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, China.
Fengcheng ChuOrthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, China.
Huan ZhouCenter for Health Sciences and Engineering (CHSE), Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, China.
Huajian GaoMechano-X Institute, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing, China.
Lei YangOrthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, this knowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomaterials by leveraging mechanics-geometry-biofunction relationships, which are beginning to shape the newly emerging field of mechanobiomaterials. To profile this emerging field, this article aims to elucidate the fundamental principles in modulating biological responses with material-tissue mechanical interactions, illustrate recent findings on the relationships between material properties and biological responses, discuss the importance of mathematical/physical models and numerical simulations in optimizing material properties and geometry, and outline design strategies for mechanobiomaterials and their potential for tissue repair and regeneration. Given that the field of mechanobiomaterials is still in its infancy, this article also discusses open questions and challenges that need to be addressed.

Indexed as

BiomaterialsMechanicsMechanobiologyMechanobiomaterialsTissue repair and regeneration

Identifiers

PMID40395492
PMCPMC12082327

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.