Evidence map›Paper›PMID 40395669›Full record

ArticleiScience2025

Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide.

Yan Rong, Zixin Zhang, Hugo R de Jonge, Ruxian Lin, Huimin Yu, Rafiq Sarker, Dario Boffelli, Rachel K Zwick, Ophir D Klein, Chung-Ming Tse and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Outer membrane vesicles secreted byInfection and immunity · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yan RongDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Zixin ZhangDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Hugo R de JongeDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, P. O. Box 2040, 3000CA Rotterdam, the Netherlands.
Ruxian LinDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Huimin YuDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Rafiq SarkerDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Dario BoffelliDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA 94143, USA.
Rachel K ZwickProgram in Craniofacial Biology and Department of Orofacial Science, University of California, San Francisco, CA 94143, USA.
Ophir D KleinDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA 94143, USA.
Chung-Ming TseDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Mark DonowitzDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.
Varsha SinghDivision of Gastroenterology & Hepatology, Department of Medicine, Baltimore, MD 21205, USA.

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2011 to 2020
$12.0M
Mechanisms and Correction of Abnormal Bicarbonate Secretion by DRA in DiarrheaR01DK116352 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TSE, CHUNG-MING · 2019 to 2022
$2.2M
NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK116352
6 · The paper itself

Abstract

Constipation causes significant morbidity in patients with cystic fibrosis (CF). Using CF patient (F508del) derived

Indexed as

GeneticsMolecular biology

Identifiers

PMID40395669
PMCPMC12090326

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.