Evidence map›Paper›PMID 40396221›Full record

ArticlePaediatric and perinatal epidemiology2025

Incidence, Risk Factors and Outcomes of SARS-CoV-2 Infection in Pregnant Women: The COROPREG Population-Based Study.

Caroline Diguisto, Pierre-Yves Ancel, Aurélien Seco, Nathalie Baunot, Cecile Caze, Catherine Crenn-Hébert, Corinne Dupont, Charles Garabedian, Cécile Lebeaux, Camille Le Ray and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463758 (Covid-19 in Pregnancy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04463758 completednot on this map

Covid-19 in Pregnancy: a French Population-based Cohort of Women and Newborns

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2020 to 2022Enrolled6,015Conditionscovid19 Infection, Pregnancy Complications, Neonatal ComplicationsArmsAn auto-questionnaire comprising three psychometric scales
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Caroline DiguistoObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.ORCID https://orcid.org/0000-0002-1176-0991
Pierre-Yves AncelObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.
Aurélien SecoClinical Research Unit Necker Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
Nathalie BaunotRéseau de Santé en Périnatalité Parisien, Paris, France.
Cecile CazeRéseau de Santé en Périnatalité Naître dans l'Est Parisien, Paris, France.
Catherine Crenn-HébertAssistance Publique-Hôpitaux de Paris, Louis Mourier University Hospital, Colombes, France.
Corinne DupontResearch on Healthcare Performance (RESHAPE), INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France.
Charles GarabedianDepartment of Obstetrics, ULR 2694-METRICS, CHU Lille, University of Lille, Lille, France.
Cécile LebeauxNeonatal Intensive Care Unit, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Camille Le RayObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.ORCID https://orcid.org/0000-0003-0891-1063
Mathilde LetouzeyObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.
Elsa LortheObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.ORCID https://orcid.org/0000-0002-9654-8104
Emilie MarrerRéseau Périnatal Lorrain/Coordination Périnatale Grand Est, Nancy, France.
Valérie RougerLoire Infant Follow-Up Team (LIFT) Network, Nantes, France.
Christophe VayssièreDepartment of Obstetrics and Gynecology, Paule de Viguier Hospital, Toulouse III University, Toulouse, France.
Christelle Vauloup FellousDepartment of Virology, Hopital Paul Brousse, Villejuif, France.
Marie-Pierre BonnetObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.
Catherine Deneux-TharauxObstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epidémiologie et StatistiqueS (CRESS), INSERM, INRAE, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.ORCID https://orcid.org/0000-0002-6561-3321

Funding

French ministry of Health, Programme Hospitalier de Recherche CliniqueCovid-19-20082
6 · The paper itself

Abstract

backgroundPopulation-based data are needed to reliably assess the impact of SARS-CoV-2 infection during pregnancy.

objectivesTo estimate the population-based incidence of SARS-CoV-2 infection and its severe forms in the obstetric population, identify risk factors of severe SARS-CoV-2 infection (severe COVID-19) and describe delivery, maternal and neonatal outcomes by disease severity, using a definition of severity based on organ dysfunction.

methodsA prospective population-based study conducted over the three first pandemic waves between March 2020 and April 2021 in 281 maternity hospitals in six French regions included all women with SARS-CoV-2 infection during pregnancy or within 7 days post-partum, whether symptomatic or not, hospitalised or not. Severe COVID-19 forms were defined a priori using clinical, biological and management criteria of organ dysfunction. We calculated infection and severe infection rates and studied associations between sociodemographic, medical and pregnancy characteristics and severe COVID-19 by univariate and multivariate modified Poisson regression modelling.

resultsFrom a population of 385,214 deliveries in the participating regions, 6015 women with SARS-CoV-2 infection were identified, including 337 severe cases. The rates of severe COVID-19 were 1.1, 0.9 and 3.6 per 1000 deliveries during the first, second and third pandemic waves, respectively, and the proportions of severe COVID-19 were 8.6%, 3.4% and 9.3%, respectively. On multivariate analysis, the risk of severe COVID-19 was associated with younger and older age, migrant status, living with > 4 people, overweight or obesity, chronic hypertension or diabetes and infection ≥ 22 weeks of gestation rather than earlier in pregnancy. Neonatal morbidity occurred mostly with severe maternal infection.

conclusionUsing an organ-based definition of severity and population-based data, rates of severe COVID-19 appeared lower than in previous studies. A permanent perinatal surveillance system is needed to assess efficiently and rapidly the impact of future pandemics.

Indexed as

COVID-19Pregnancy Complications, InfectiousAdultFemaleFranceHumansIncidenceInfant, NewbornPregnancyPregnancy OutcomeProspective StudiesRisk FactorsSARS-CoV-2Severity of Illness IndexYoung AdultCOVID‐19maternal morbidityneonatal morbiditypregnancyrisk factorsSARS‐CoV‐2

Identifiers

PMID40396221
PMCPMC12308625

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.