Evidence mapPaperPMID 40397123Full record

ReviewTechnology in cancer research & treatment

miR-10b as a Clinical Marker and a Therapeutic Target for Metastatic Breast Cancer.

Alan Halim, Bryan Kim, Elizabeth Kenyon, Anna Moore

Abstract readReview
In one paragraph

Review in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alan HalimPrecision Health Program, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-9419-4552
Bryan KimPrecision Health Program, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-8282-3366
Elizabeth KenyonPrecision Health Program, Michigan State University, East Lansing, MI, USA.
Anna MoorePrecision Health Program, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-5218-7204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in cancer detection and treatment, metastatic breast cancer continues to carry a poor prognosis due to the lack of diagnostic and therapeutic resources that are specific to the metastatic process. MicroRNA-10b (miR-10b) is a small, noncoding RNA that is the focus of many studies due to its unique role as a driver of metastasis. The pathways it is involved in and the properties it confers have been reviewed previously and, collectively, are suggestive of the potential of miR-10b as a clinical marker and as a therapeutic target specific to metastatic disease. With the goal of application of our understanding of miR-10b to the clinic, in this mini-review, we highlight the studies that support the utility of miR-10b for these translational purposes.

Indexed as

Biomarkers, TumorBreast NeoplasmsMicroRNAsFemaleGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyNeoplasm MetastasisPrognosisBiomarkers, TumorMicroRNAsMIRN10 microRNA, humanbiomarkerbreast cancercancer therapymetastasismicroRNA

Identifiers

PMID40397123
PMCPMC12099151

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.