ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Vitreoretinal interface features in epiretinal membrane associated with pseudoexfoliation syndrome.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Epiretinal membrane prevalence in asymmetrical pseudoexfoliation glaucoma and its impact on glaucoma monitoring parameters including peripapillary vessel density.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Frequency of Exfoliation Syndrome Among Patients Attending an Ophthalmology Outpatient Clinic in the Northeastern Black Sea Coast of Turkey.Healthcare (Basel, Switzerland) · 2026Article
- Ultrastructural Findings of the Internal Limiting Membrane with and without Epiretinal Membrane: A Comparative Electron Microscopy Study.Ophthalmology science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the morphology and histopathology of the vitreoretinal interface (VRI) in eyes with pseudoexfoliation syndrome (PEX) and epiretinal membrane (ERM) (pERM) in comparison to eyes without PEX and idiopathic ERM (iERM).
methodsSpecimens of ERM and internal limiting membrane (ILM) were obtained during pars plana vitrectomy with membrane peeling from 10 symptomatic eyes with pERM and 16 eyes with iERM. Specimens were processed as flat-mounts for immunocytochemistry and prepared by ultrathin series sectioning for transmission electron microscopy (TEM). Cellular and extracellular composition were compared and correlated with clinical data.
resultsThe extracellular distribution of the VRI showed significant differences between pERM and iERM in the following aspects. Immunostaining revealed that all pERM specimens were positive for fibrillin-1, collagen IV and TGFβ1, which are key regulatory factors or structural components of the extracellular matrix, while these markers were rarely detected positive in the iERM group. Glial cell markers, GFAP and vimentin, were consistently positive in both groups. TEM revealed abundant vitreous collagen and evidence of vitreous remodeling in pERM eyes, including the presence of fibrous long-spacing collagen (FLSC). In contrast, iERM specimens showed sparse collagen strands with no evidence of FLSC.
conclusionsEyes with pERM showed excessive production and subsequent accumulation of extracellular matrix material and elastic proteins such as fibrilin compared to eyes with iERM. Our data suggest that PEX may affect the VRI in a manner similar to the anterior segment, based on the detection and alteration of common structures such as collagen in the pERM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.