Evidence map›Paper›PMID 40397565›Full record

ArticleMolecular biology of the cell2025

Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions.

Mar Martinez Pastor, Cynthia L Darnell, Angie Vreugdenhil, Amy K Schmid

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mar Martinez PastorDepartment of Biology, Duke University, Durham, NC 27708.
Cynthia L DarnellDepartment of Biology, Duke University, Durham, NC 27708.
Angie VreugdenhilDepartment of Biology, Duke University, Durham, NC 27708.
Amy K SchmidDepartment of Biology, Duke University, Durham, NC 27708.ORCID 0000-0001-5821-8000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For microbial cells, an appropriate response to changing environmental conditions is critical for viability. Transcription regulatory proteins, or transcription factors (TF) sense environmental signals to change gene expression. However, it remains unclear how TFs and their corresponding gene regulatory networks are selected over evolutionary time scales. The function of TFs and how they evolve are particularly understudied in archaeal organisms. Here, we identified, characterized, and compared the function of the RosR TF across three related hypersaline-adapted archaeal model species. RosR was previously characterized as a global regulator of gene expression during oxidative stress in the species

Indexed as

Archaeal ProteinsTranscription FactorsGene Expression Regulation, ArchaealGene Regulatory NetworksHalobacterium salinarumHaloferaxHaloferax volcaniiOxidative StressArchaeal ProteinsTranscription Factors

Identifiers

PMID40397565
PMCPMC12260171

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.