Evidence map›Paper›PMID 40399229›Full record

ArticleUltrasound in medicine & biology2025

Quantitative Ultrasound-Based Characterization of Placental Tissue Microstructure in a Rat Model of Preeclampsia.

Andrew C Markel, Cameron Hoerig, Allan K N de Alencar, Kenneth F Swan, Alexander D Gleed, Lili Shi, Gabriella Pridjian, Jonathan Mamou, Carolyn L Bayer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew C MarkelDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Cameron HoerigDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Allan K N de AlencarDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Kenneth F SwanDepartment of Obstetrics and Gynecology, Tulane University, New Orleans, LA, USA.
Alexander D GleedDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Lili ShiDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Gabriella PridjianDepartment of Obstetrics and Gynecology, Tulane University, New Orleans, LA, USA.
Jonathan MamouDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Carolyn L BayerDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA. Electronic address: carolynb@tulane.edu.

Funding

Placental Functional Imaging to Predict Preeclampsia Therapeutic OutcomesR01HD097466 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE · 2019 to 2023
$1.6M
Quantitative Ultrasound for Assessment of Placental Structure During the Development of PreeclampsiaR21HD114007 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE, MAMOU, JONATHAN · 2023 to 2023
$443k
NICHD NIH HHS R01 HD097466NICHD NIH HHS R21 HD114007
6 · The paper itself

Abstract

objectiveQuantitative ultrasound (QUS) methods were applied to detect changes in placental microstructure in the reduced uterine perfusion pressure (RUPP) model of preeclampsia in rats. Preeclampsia is a life-threatening pregnancy disorder associated with abnormal placental development that is inadequately treated and managed.

methodsNine timed-pregnant Sprague-Dawley rats were used in this study. On gestational day 14 (GD 14), five rats received RUPP surgery to induce preeclampsia. US radiofrequency data were acquired for QUS analysis on GD18. On GD19, animals were sacrificed and dissected to acquire placental tissue samples. The cell nuclear diameter in each anatomical layer of the placenta was measured to compare with regional effective scatterer diameter (ESD) values.

resultsESD measurements obtained using in vivo QUS imaging correlated well (R

conclusionThese results demonstrate the potential of QUS as a non-invasive tool for detecting critical changes in placental microstructure, improving maternal and fetal outcomes by enabling earlier diagnosis and more timely therapeutic interventions in preeclampsia.

Indexed as

PlacentaPre-EclampsiaUltrasonography, PrenatalAnimalsDisease Models, AnimalFemalePregnancyRatsRats, Sprague-DawleyUltrasonographyBackscatter coefficientEffective scatterer diameterPlacentaPreeclampsiaQuantitative ultrasoundReduced uterine perfusion pressureTissue characterizationTissue microstructure

Identifiers

PMID40399229
PMCPMC12551963

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.