Evidence map›Paper›PMID 40399597›Full record

ArticleDiabetologia2025

Skeletal muscle mitochondrial health in type 1 diabetes: the role of exercise capacity and lifestyle factors.

Richie P Goulding, Braeden T Charlton, Ellen A Breedveld, Jelle Y Huijts, Matthijs van der Laan, Anne R Strating, Wendy Noort, Aryna Kolodyazhna, Anita E Grootemaat, Frank W Bloemers and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Richie P GouldingDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands. r.p.goulding@vu.nl.ORCID http://orcid.org/0000-0003-1697-0848
Braeden T CharltonDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-4242-3664
Ellen A BreedveldDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.ORCID http://orcid.org/0009-0006-2516-0694
Jelle Y HuijtsDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.ORCID http://orcid.org/0009-0003-8357-1465
Matthijs van der LaanDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.
Anne R StratingDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.
Wendy NoortDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.
Aryna KolodyazhnaDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.
Anita E GrootemaatElectron Microscopy Centre Amsterdam, Amsterdam UMC, Location Academic Medical Centre, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-4209-8232
Frank W BloemersDepartment of Trauma Surgery, Amsterdam Movement Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-8393-4946
Nicole N van der WelElectron Microscopy Centre Amsterdam, Amsterdam UMC, Location Academic Medical Centre, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6392-3417
Rob C I WüstDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands. r.wust@vu.nl.ORCID http://orcid.org/0000-0003-3781-5177

Funding

European Association for the Study of Diabetes European Foundation for the Study of Diabetes/Boeh
6 · The paper itself

Abstract

aims/hypothesisPrevious studies reporting lower skeletal muscle mitochondrial function in type 1 diabetes did not account for cardiorespiratory fitness, a key confounder when assessing mitochondrial function. We hypothesised that, compared with healthy individuals, muscle mitochondrial phenotypic differences would be abolished in individuals with type 1 diabetes when matched for age, sex, BMI and maximal oxygen uptake (

methodsSeventeen individuals with type 1 diabetes and seventeen healthy control individuals matched for age, sex, BMI and

resultsCONCLUSIONS/

interpretationCollectively, our study demonstrates that when matched for age, sex, BMI and

Indexed as

Diabetes Mellitus, Type 1ExerciseLife StyleMitochondria, MuscleMuscle, SkeletalAdultFemaleHumansMaleOxidative PhosphorylationOxygen ConsumptionYoung AdultMaximal oxygen uptakeMitochondrial densityMitochondrial respirationMuscle bioenergeticsMuscle mitochondriaSkeletal muscleType 1 diabetes

Identifiers

PMID40399597
PMCPMC12246007

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.