Evidence map›Paper›PMID 40399609›Full record

ArticleNature immunology2025

Cholinergic regulation of thymocyte negative selection.

Shaofeng Liu, Chunxing Zheng, Robert Nechanitzky, Ping Luo, Parameswaran Ramachandran, Dat Nguyen, Andrew J Elia, Soode Moghadas Jafari, Rhoda Law, Bryan E Snow and 16 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Shaofeng LiuPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Chunxing ZhengPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-8668-0873
Robert NechanitzkyPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ping LuoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Parameswaran RamachandranPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Dat NguyenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Andrew J EliaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Soode Moghadas JafariPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Rhoda LawPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Bryan E SnowPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Andrew C WakehamPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Thorsten BergerPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Hui ChenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Kyle T GillPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ryan McwilliamPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Jerome FortinPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Nastaran Fazel ModaresPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Mary E SaundersPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Kiichi MurakamiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Yangmin QiuDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6039-7909
Zhiwei YouSchool of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China.
Mahmood MohtashamiBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7952-1869
Hai QiSchool of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-5475-3989
Pamela S OhashiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Juan Carlos Zúñiga-PflückerDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2538-3178
Tak W MakPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Tak.Mak@uhn.ca.ORCID http://orcid.org/0000-0001-6766-861X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune and nervous systems use a common chemical language for communication, namely, the cholinergic signaling involving acetylcholine (ACh) and its receptors (AChRs). Whether and how this language also regulates the development of the immune system is poorly understood. Here, we show that mouse CD4

Indexed as

AcetylcholineReceptors, NicotinicThymocytesThymus GlandAnimalsCD8-Positive T-LymphocytesCell DifferentiationCholine O-AcetyltransferaseMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionAcetylcholineCholine O-AcetyltransferaseReceptors, Antigen, T-CellReceptors, Nicotinic

Identifiers

PMID40399609

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.