Evidence map›Paper›PMID 40399675›Full record

ArticleNature2025

Programmable control of spatial transcriptome in live cells and neurons.

Mengting Han, Maylin L Fu, Yanyu Zhu, Alexander A Choi, Emmy Li, Jon Bezney, Sa Cai, Leann Miles, Yitong Ma, Lei S Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Subcellular localization as a driver of protein function.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Reprogramming mRNA localization by targeted RNA-protein interference.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengting HanDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Maylin L FuDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3749-5003
Yanyu ZhuDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8681-976X
Alexander A ChoiDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Emmy LiDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Jon BezneyDepartment of Genetics, Stanford University, Stanford, CA, USA.
Sa CaiDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Leann MilesDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7554-4051
Yitong MaDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4446-7326
Lei S QiDepartment of Bioengineering, Stanford University, Stanford, CA, USA. stanley.qi@stanford.edu.ORCID 0000-0002-3965-3223

Funding

Manipulating and Interrogating Spatial TranscriptomicsDP1NS137219 · NINDS · STANFORD UNIVERSITY · PI Lei Stanley Qi · 2023 to 2026
$4.3M
High resolution dissection of oncogene enhancer networks via CRISPR screening and live-cell imaging.R01CA266470 · NCI · STANFORD UNIVERSITY · PI Lei Stanley Qi · 2022 to 2026
$1.9M
Super-resolution, structured illuminationmicroscope (SIM) for biomedical researchS10OD034400 · OD · STANFORD UNIVERSITY · PI MULHOLLAND, JONATHAN W · 2024 to 2024
$750k
ImageXpress Micro (IXM) Confocal High-content Imaging SystemS10OD026899 · OD · STANFORD UNIVERSITY · PI SOLOW-CORDERO, DAVID EDWARD · 2019 to 2019
$541k
Development of multi-color 3D super-localization LiveFISH and LiveFISH PAINT to investigate the chromatin dynamics at any genomic scaleR21HG013133 · NHGRI · STANFORD UNIVERSITY · PI QI, LEI STANLEY · 2023 to 2023
$420k
NCI NIH HHS R01 CA266470NHGRI NIH HHS R21 HG013133NIH HHS S10 OD026899NIH HHS S10 OD034400NINDS NIH HHS DP1 NS137219
6 · The paper itself

Abstract

Spatial RNA organization has a pivotal role in diverse cellular processes and diseases

Indexed as

CRISPR-Cas SystemsNeuronsTranscriptomeActinsAnimalsAxonsCells, CulturedFemaleHumansMiceMicrotubulesNeuritesNeuronal OutgrowthProtein BiosynthesisRatsRibosomesActinsRNA, Messenger

Identifiers

PMID40399675
PMCPMC12882822

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.