Evidence mapPaperPMID 40399945Full record

Trial reportThe international journal of behavioral nutrition and physical activity2025

Effect of physical activity on changes in weight and aerobic capacity during an 18-month behavioral weight loss intervention.

Seth A Creasy, Danielle M Ostendorf, Laura Kaizer, Rebecca Rosenberg, Matthew J Breit, Daniel H Bessesen, Edward L Melanson, Victoria A Catenacci

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in The international journal of behavioral nutrition and physical activity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01985568 (Optimal Timing of Exercise Initiation Within a Lifestyle Weight Loss Program), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01985568 nacompletednot on this map

Optimal Timing of Exercise Initiation Within a Lifestyle Weight Loss Program

TypeinterventionalSponsorUniversity of Colorado, DenverRan2013 to 2018Enrolled170ConditionsObesityArmsSequential BT, Standard BT
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seth A CreasyDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA. seth.creasy@cuanschutz.edu.ORCID http://orcid.org/0000-0002-4176-0917
Danielle M OstendorfDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA.
Laura KaizerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rebecca RosenbergDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA.
Matthew J BreitDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA.
Daniel H BessesenDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA.
Edward L MelansonDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA.
Victoria A CatenacciDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12348 E. Montview Blvd., Aurora, CO, 80045, USA.

Funding

Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$7.7M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
Research Training Program in Metabolism, Obesity and DiabetesT32DK120521 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$366k
Linking temporal patterns of modifiable behaviors to weight loss outcomesK01HL145023 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Seth A Creasy · 2023 to 2023
$170k
Designing with dissemination in mind: Development and evaluation of a theory-based physical activity intervention using the Multiphase Optimization StrategyK01HL161417 · UNIVERSITY OF TENNESSEE KNOXVILLE · 2025 to 2025
$165k
Training the Next Generation of Innovative and Collaborative Patient-Oriented Researchers to Reduce Obesity and Improve Cardiometabolic HealthK24HL169755 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$126k
NCATS NIH HHS UM1 TR004399NHLBI NIH HHS K01 HL145023NHLBI NIH HHS K01 HL161417NHLBI NIH HHS K24 HL169755NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30DK048520NIDDK NIH HHS R01 DK097266NIDDK NIH HHS T32 DK120521
6 · The paper itself

Abstract

backgroundThe objective of this secondary analysis was to examine the effect of MVPA and the time of day that MVPA (i.e., morning vs. evening) is performed on long-term changes in body weight and aerobic capacity.

methodsAdults with overweight and obesity (n = 105) enrolled in an 18-month behavioral weight loss intervention involving a reduced calorie diet and a supervised exercise program. Participants were encouraged to increase their bouted MVPA (i.e., MVPA accumulated in bouts ≥ 10 min) to 300 min/wk. Body weight, body composition, aerobic capacity, and physical activity were assessed at 0, 6, 12, and 18 months. Participants were categorized based on whether they increased bouted MVPA by ≥ 150 min/wk during the supervised exercise program. Linear regression was used to examine the effect of increasing bouted MVPA on weight loss and aerobic capacity. Similar methods were used to examine the effect of time of day of MVPA on weight loss and aerobic capacity.

resultsParticipants who increased bouted MVPA by ≥ 150 min/wk during the supervised exercise program had greater weight loss, fat loss, and increases in aerobic capacity at 18 months compared to participants who increased bouted MVPA by < 150 min/wk. Amongst participants who increased bouted MVPA by ≥ 150 min/wk, the time of day of MVPA had no significant effect on weight loss or aerobic capacity.

conclusionsIncreasing bouted MVPA by ≥ 150 min/wk improves weight loss and aerobic capacity during a behavioral weight loss intervention which includes caloric restriction. MVPA earlier and later in the day is beneficial for weight management and cardiorespiratory fitness.

trial registrationClinicaltrials.gov (NCT01985568) on October 24, 2013.

Indexed as

ExerciseObesityOverweightWeight LossWeight Reduction ProgramsAdultBody CompositionDiet, ReducingFemaleHumansMaleMiddle AgedExerciseLifestyle treatmentObesityTiming

Identifiers

PMID40399945
PMCPMC12093688

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.