ArticleItalian journal of pediatrics2025
Correlation between preoperative and postoperative miR-29c-3p level changes and immune response in paediatric acute septic appendicitis and its predictive significance for complications: a retrospective study.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPostoperative complications in children with acute suppurative appendicitis (ASA) can lead to very serious consequences. In this study, we investigated the pre- and postoperative expression of miR-29c-3p in ASA and its value in predicting postoperative complications.
methodsRetrospectively, 128 children with ASA and 93 healthy children were included. The qRT-PCR technique was used to detect miR-29c-3p expression in children with ASA preoperatively and 24 h postoperatively. The levels of immune cells (WBC, NEU, LYM) were detected by routine blood test, and the levels of immune proteins CRP and inflammatory factors (TNF-α and IL-6) were detected by ELISA.
resultsBefore surgery, children with ASA had higher levels of miR-29c-3p than healthy controls. But after surgery, miR-29ac-3p levels dropped a lot in children with ASA. The serum levels of immune cells (WBC, NEU, LYM), immune protein CRP and inflammatory factors (TNF-α and IL-6) were significantly decreased in children with ASA. Postoperative miR-29c-3p levels were positively correlated with the levels of immune indicators. The patients with higher miR-29c-3p expression levels showed a greater incidence of postoperative complications.
conclusionsThe expression of miR-29c-3p was positively correlated to immune cells, immune proteins, and inflammatory factors. The expression levels of miR-29c-3p were related to the occurrence of postoperative complications and could, therefore, be utilized to predict the occurrence of postoperative complications in children with ASA.
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