SynthesisActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2025
Surgical margins after open versus transoral surgery for oropharyngeal cancer and their impact on the need for multimodal treatments.
Synthesis in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Resection margins in transoral oropharyngeal surgery: comparative analysis of robotic and VITOM Eagle-assisted exoscopic approaches.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: In oropharyngeal squamous cell carcinoma (OPSCC), proper definition of surgical margins may have substantial impact on oncologic outcomes. Minimally-invasive techniques prioritise reduced morbidity, yet open approaches remain significant due to limited large-scale evidence comparing their outcomes with transoral methods. The purpose of the present systematic review was to assess the incidence of positive margins in OPSCC management based on surgical approach (open Methods: Medical databases were searched including PubMed, Scopus, EMBASE, and Cochrane Library from January 2000 to August 2024. Data analysis was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis, and the quality of studies was evaluated using the Newcastle-Ottawa Scale. Results: Four studies, including 305 patients (126 treated by an open approach, and 179 by transoral surgery), were qualitatively analysed. No significant difference was found in the rates of positive margins (p = 0.422) or need for adjuvant therapy (p = 0.368) between the two approaches. It was not feasible to conduct a meta-analysis due to significant inconsistencies in the reporting of data across the studies included. Conclusions: Transoral approach is recommended for early-stage OPSCC when adequate exposure is achievable, although its impact on positive surgical margins remains unclear. The management of close or positive margins remains debated due to the oropharyngeal unique anatomy and function, with no clear de-intensification protocol established.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.