SynthesisFrontiers in medicine2025
Artificial intelligence versus manual screening for the detection of diabetic retinopathy: a comparative systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinical setting-dependent diagnostic accuracy of artificial intelligence and store-and-forward diabetic retinopathy screening: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
- Diagnostic Agreement Between a General-Purpose AI Model and Retinal Specialists in Color Fundus Photography-A Pilot Study.Journal of clinical medicine · 2026Article
- Real-world performance of an AI system for diabetic retinopathy screening.Scientific reports · 2026Article
- Artificial intelligence-based analysis of retinal vascular changes in the preclinical and early stages of diabetic retinopathy using ultra-widefield fundus imaging: an observational cross-sectional study.Frontiers in medicine · 2026Article
- Is AI overhyped?Patterns (New York, N.Y.) · 2025Article
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Authors and funding
9 authors.
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Abstract
Background: Diabetic retinopathy is one of the leading causes of blindness globally, among individuals with diabetes mellitus. Early detection through screening can help in preventing disease progression. In recent advancements artificial Intelligence assisted screening has emerged as an alternative to traditional manual screening methods. This diagnostic test accuracy (DTA) review aims to compare the sensitivity and specificity of AI versus manual screening for detecting diabetic retinopathy, focusing on both dilated and un-dilated eyes. Methods: A systematic review and meta-analysis were conducted for comparison of AI vs. manual screening of diabetic retinopathy using 25 observational (cross sectional, validation and cohort) studies with total images of 613,690 used for screening published between January 2015 and December 2024. Outcomes of the study was sensitivity, and specificity. Risk of bias was assessed using the QUADAS-2 tool for validation studies, the AXIS tool for cross-sectional studies, and the Newcastle-Ottawa Scale for cohort studies. Results: The results of this meta-analysis showed that for un-dilated eyes, AI screening showed pooled sensitivity of 0.90 [95% CI: 0.85-0.94] and pooled specificity of 0.94 [95% CI: 0.91-0.96] while manual screening shows pooled sensitivity of 0.79 [95% CI: 0.60-0.91] and pooled specificity of 0.99 [95% CI: 0.98-0.99]. For dilated eyes the pooled sensitivity of AI screening is 0.95 [95% CI: 0.91-0.97] and pooled specificity is 0.87 [95% CI: 0.79-0.92], while manual screening sensitivity is 0.90 [95% CI: 0.87-0.92] and specificity is 0.99 [95% CI: 0.99-1.00]. These data show comparable sensitivities and specificities of AI and manual screening, with AI performing better in sensitivity. Conclusion: AI-assisted screening for diabetic retinopathy shows comparable sensitivity and specificity compared to manual screening. These results suggest that AI can be a reliable alternative in clinical settings, with increased early detection rates and reducing the burden on ophthalmologists. Further research is needed to validate these findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/home, CRD42024596611.
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