ArticleFrontiers in sports and active living2025
Effect of exercise on postprandial lipaemia in children with sickle cell disease.
Article in Frontiers in sports and active living, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Elevated plasma triacylglycerol (TAG) levels are associated with endothelial dysfunction, inflammation, and increased vascular complications, particularly in populations such as individuals with sickle cell disease (SCD). This study aimed to investigate the effect of a single exercise session on postprandial TAG levels in children with SCD following the consumption of a high-fat meal. The high-fat meal was used to induce a significant postprandial increase in plasma triayglecrol (TAG) levels, aknown risk factor for endothelial dysfunction and vascular implication, particualry in population with Sickle Cell Disease (SCD). Twelve male children with SCD (mean age: 10.5 ± 1.2 years) participated in two 2-day trials, one involving brisk walking (exercise trial) and one with rest (rest trial), in a randomized, counter-balanced design. A mixed high-fat test meal (97 g fat, 124 g carbohydrate, 1,450 kcal) was administered after a 10-h overnight fast, and blood samples were collected at baseline, 60, 120, 240, 300, and 360 min post-meal to measure serum TAG, glucose, insulin, and total cholesterol concentrations. Postprandial TAG levels significantly increased in both trials, but the exercise trial showed a significantly lower TAG response compared to the rest trial (
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