Evidence map›Paper›PMID 40400796›Full record

ArticleCureus2025

Sirtuin Expression in Age-Associated Hepatic Response to Burn Trauma: Translational and Clinical Insights From a Murine Model.

Kenneth Meza Monge, Andrea C Qualman, Akshay Pratap, Elizabeth J Kovacs, Juan-Pablo Idrovo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Subclinical Hepatic Injury and Dysfunction Following Surgery: Evidence From a Young and Aged Laparotomy Murine Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenneth Meza MongeDepartment of Surgery, Division of Gastrointestinal, Trauma, and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, USA.
Andrea C QualmanDepartment of Surgery, Division of Gastrointestinal, Trauma, and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, USA.
Akshay PratapDepartment of Surgery, Division of Gastrointestinal, Trauma, and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, USA.
Elizabeth J KovacsDepartment of Surgery, Division of Gastrointestinal, Trauma, and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, USA.
Juan-Pablo IdrovoDepartment of Surgery, Division of Gastrointestinal, Trauma, and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Burn injuries can lead to substantial liver damage, and this response appears to worsen with age. Although clinical patterns suggest that older individuals are more susceptible to poor outcomes, the biological mechanisms contributing to this increased vulnerability are poorly understood. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD

Indexed as

agingapoptosisburn injurygene expressionhepatic damageinflammationliver injuryoxidative stresssirtuinstrauma

Identifiers

PMID40400796
PMCPMC12094498

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.