ArticleFrontiers in public health2025
The association between frailty index and abdominal aortic calcification in the middle-aged and older US adults: NHANES 2013-2014.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Machine learning derived abdominal aortic calcification is associated with physical frailty in community-dwelling adults: the UK Biobank Imaging Study.GeroScience · 2026Article
- Association between frailty index and erectile dysfunction: A cross-sectional study using NHANES 2001 to 2004 data.Medicine · 2026Article
- Comment on 'integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure'.Annals of medicine · 2025Article
- The ratio of serum uric acid to high-density lipoprotein cholesterol as a predictor for frailty prevalence and mortality in the elderly U.S. adults.Lipids in health and disease · 2025Article
- Development and validation of a model to predict the risk of frailty in older adults with panvascular disease.Frontiers in public health · 2025Article
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Authors and funding
8 authors.
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Abstract
Background: Abdominal aortic calcification (AAC) is one of the earliest observed forms of atherosclerotic calcification and is crucial for early cardiovascular risk prediction. Frailty, a global clinical and public health challenge, is associated with increased risks of mortality, functional decline, and loss of independence. However, the relationship between the Frailty Index (FI) and AAC among middle-aged and older adults has yet to be explored. Methods: This study analyzed data from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES) cohort, focusing on individuals aged ≥ 40 years. The FI was calculated using a 49-item model to assess frailty status and participants were stratified into three groups: non-frail (FI ≤ 0.15), pre-frail (0.15 < FI ≤ 0.25), and frail (FI > 0.25). AAC was measured by dual-energy X-ray absorptiometry and quantified by Kauppila scores. Severe AAC was defined as an AAC score > 6. The relationship between FI and AAC was investigated using multivariable logistic regression, sensitivity analyses, and smoothing curve fitting. Subgroup analyses and interaction tests were conducted to assess the stability of this association across different populations. Results: A total of 2,572 participants were enrolled in this study. Following adjustment for potential confounders, FI exhibited a statistically significant positive association with both AAC score (β = 2.64, 95%CI = 1.20-4.08) and Severe AAC (OR = 6.36, 95%CI = 1.48-27.41). Similar trends ( Conclusion: Our study indicated a stable positive correlation between FI and AAC. FI may serve as a biomarker for early subclinical atherosclerosis detection in middle-aged and older US adults.
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