Evidence map›Paper›PMID 40401266›Full record

ReviewDigital discovery2025

Artificial intelligence approaches for anti-addiction drug discovery.

Dong Chen, Jian Jiang, Nicole Hayes, Zhe Su, Guo-Wei Wei

Abstract readReview
In one paragraph

Review in Digital discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Dong ChenDepartment of Mathematics, Michigan State University MI 48824 USA weig@msu.edu.ORCID https://orcid.org/0000-0001-5397-0447
Jian JiangDepartment of Mathematics, Michigan State University MI 48824 USA weig@msu.edu.
Nicole HayesDepartment of Mathematics, Michigan State University MI 48824 USA weig@msu.edu.ORCID https://orcid.org/0000-0003-1772-0306
Zhe SuDepartment of Mathematics, Michigan State University MI 48824 USA weig@msu.edu.ORCID https://orcid.org/0000-0003-3499-6814
Guo-Wei WeiDepartment of Mathematics, Michigan State University MI 48824 USA weig@msu.edu.ORCID https://orcid.org/0000-0001-8132-5998

Funding

AI-based platform for predicting emerging vaccine-escape variants and designing mutation-proof antibodiesR01AI164266 · NIAID · UNIVERSITY OF GEORGIA · PI Guowei Wei, YONG-HUI ZHENG · 2022 to 2026
$2.7M
Discovery-Driven Mathematics and Artificial Intelligence for Biosciences and Drug DiscoveryR35GM148196 · NIGMS · UNIVERSITY OF GEORGIA · PI Guowei Wei · 2023 to 2026
$1.5M
Synergistic integration of topology and machine learning for the predictions of protein-ligand binding affinities and mutation impactsR01GM126189 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WEI, GUOWEI · 2018 to 2021
$1.4M
NIAID NIH HHS R01 AI164266NIGMS NIH HHS R01 GM126189NIGMS NIH HHS R35 GM148196
6 · The paper itself

Abstract

Drug addiction remains a complex global public health challenge, with traditional anti-addiction drug discovery hindered by limited efficacy and slow progress in targeting intricate neurochemical systems. Advanced algorithms within artificial intelligence (AI) present a transformative solution that boosts both speed and precision in therapeutic development. This review examines how artificial intelligence serves as a crucial element in developing anti-addiction medications by targeting the opioid system along with dopaminergic and GABAergic systems, which are essential in addiction pathology. It identifies upcoming trends promising in studying less-researched addiction-linked systems through innovative general-purpose drug discovery techniques. AI holds the potential to transform anti-addiction research by breaking down conventional limitations, which will enable the development of superior treatment methods.

Identifiers

PMID40401266
PMCPMC12086782

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.