SynthesisSchizophrenia bulletin2026
Blunted Niacin Skin Flushing Response in Schizophrenia: A Meta-analysis.
Synthesis in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The interplay of niacin skin flush response with plasma MDA, TNOS, iNOS and clinical symptom severity in chronic schizophrenia.BMC psychiatry · 2026Article
- A transdiagnostic niacin flushing biomarker with disorder-specific multivariate relationships in adolescent unipolar and bipolar depression.BMC psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
background and hypothesisThe multifactorial pathogenesis of schizophrenia (SZ) hinders the diagnosis and treatment of this disorder. Niacin skin flushing response (NSFR) has been identified as an endophenotype for SZ, but the proportion of blunted NSFR (BNR) varied between studies. This study aims to clarify the relationship between NSFR and SZ through a meta-analysis. STUDY
designPubMed, Embase, Web of Science, Cochrane, and Scopus databases were searched for articles published until May 2024, and 32 studies were eligible. Using random-effects models, we examined the characteristics of NSFR in SZ, including the reaction degree, speed, sensitivity, and risk and prevalence of BNR. Subgroup analyses and regression analyses were performed to investigate the relevant effect factors of NSFR. STUDY
resultsThe reaction degree (SMD = -0.90; CI, -1.08 to -0.72), speed (SMD = 0.64; CI, 0.02-1.25), and sensitivity (SMD = 0.89; CI, 0.49-1.29) of NSFR was significantly reduced in SZ compared to healthy controls (HC). Moreover, we observed a positive association between BNR and SZ (OR = 8.50; CI, 5.93-12.19). The overall prevalence of BNR was 58.5% in SZ (CI, 49.3%-67.8%) compared to 11.8% in HC (CI, 7.7%-15.9%). In addition, NSFR detection method, geographical regions, and age were found to have effects on reaction degree and prevalence of BNR.
conclusionsThis study confirmed a significantly abnormal NSFR and higher prevalence of BNR in SZ, which highlights the potential facilitation of the diagnosis and personalized intervention of SZ subgroups. In addition, the study points to a need to establish a standardized method for NSFR assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.