ArticleJACC. Advances2025
Sex-Specific Coronary Artery Calcium Percentiles Across South Asian Adults: Combined Analyses From MASALA and DILWALE.
Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Rethinking the coronary artery calcium scan: from population averages to individual realities - visualizing subclinical risk in South Asian adults.American journal of preventive cardiology · 2026Article
- Coronary plaque beyond calcium: advancing precision risk assessment in South Asians.American journal of preventive cardiology · 2026Article
- Age and sex specific coronary plaque characteristics among South Asians: Insights from the DILWALE CTA study.American journal of preventive cardiology · 2026Article
- Associations of the PREVENT Score with coronary artery and thoracic aortic calcification among South Asian Americans.American journal of preventive cardiology · 2026Article
- Diverging trends in motor neuron disease burden in China: an ageing-driven increase despite declining age-standardised rates - a GBD 2021 analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Palliative Care Delivery in the Last Year of Life among Ethnically South Asian Canadians in Ontario, Canada.Journal of immigrant and minority health · 2026Article
- Association of Parity With ASCVD Risk Factors Among South Asian Women: The MASALA Study.JACC. Advances · 2026Article
- Tailoring Calcium Scores to the Race of a Nation Not a Region.Journal of the American Heart Association · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundCoronary artery calcium (CAC) testing is guideline-recommended to enhance atherosclerotic cardiovascular disease (ASCVD) risk prediction, yet there are no sex-specific CAC reference data for South Asians in the United States (SAUS) across their adult lives.
objectivesThe purpose of this study was to determine the sex-specific distribution of CAC scores across the adult lifespan of SAUS.
methodsWe studied 2743 SAUS adults (ages 33-75 years old) free of known ASCVD from the MASALA (Mediators of Atherosclerosis in South Asians Living in America), a community-based cohort study, and the DILWALE (DIL Wellness and Arterial health Longitudinal Evaluation), a clinic-based study. We estimated the likelihood of CAC >0 and calculated sex-specific CAC percentiles as a function of age, employing nonparametric methods.
resultsParticipants had a mean age of 52 ± 9 years, with 37.8% women. The probability of CAC >0 for women and men was 20% and 45% at age 50 years, 40% and 70% at age 60 years, and 70% and 90% at 70 years old, respectively. The 75th and the 90th percentiles of CAC at age 60 years were 26 and 115 for SAUS women and 186 and 580 for SAUS men. A CAC score of 100 was at approximately the 75th percentile for a 55-year-old man or a 65-year-old woman.
conclusionsThese data address the current knowledge gap regarding the distribution of CAC scores among SAUS adults. Utilizing these CAC percentiles in the clinical assessment of ASCVD risk may enhance personalized interpretation of CAC scoring and guide ASCVD prevention efforts in SAUS.
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