Evidence map›Paper›PMID 40402262›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Results of the implementation of a multidisciplinary care protocol for preventing fragility fractures following liver transplantation.

A Monegal, J L Carrasco, P Peris, B Frade-Sosa, A Azuaga, H Florez, A Dura, N Guañabens, J Colmenero

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A MonegalMetabolic Bone Diseases Unit, Department of Rheumatology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain. amonegal@clinic.cat.
J L CarrascoBiostatistics, Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain.
P PerisMetabolic Bone Diseases Unit, Department of Rheumatology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
B Frade-SosaMetabolic Bone Diseases Unit, Department of Rheumatology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
A AzuagaMetabolic Bone Diseases Unit, Department of Rheumatology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
H FlorezMetabolic Bone Diseases Unit, Department of Rheumatology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
A DuraLiver Transplant Unit, Liver Unit, ICMDM, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, 08007, Barcelona, Spain.
N GuañabensMetabolic Bone Diseases Unit, Department of Rheumatology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
J ColmeneroLiver Transplant Unit, Liver Unit, ICMDM, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, 08007, Barcelona, Spain.

Funding

Instituto de Salud Carlos III FISPI22/01234
6 · The paper itself

Abstract

Nearly 11% of subjects developed fragility fractures during the first year after LT despite following a CP. This study allowed for generating a fracture risk score, with a sensitivity of 80% and a specificity of 72%, for identifying high-risk subjects, thereby allowing a more adequate therapeutic approach in these patients. PURPOSE/

introductionThe increased risk of skeletal fractures associated with liver transplantation (LT) led our group to develop a multidisciplinary care protocol (CP) for preventing fractures after LT. The aim of this study was to evaluate the effect of applying this CP on the incidence of fractures during the first year after LT and to evaluate the risk factors for fractures in these subjects.

methodsRetrospective study of subjects referred for LT in a CP over a 7-year period. Clinical risk factors for fracture and densitometric and 25-OH vitamin D (25OHD) values were evaluated in all subjects as were spinal X-ray findings. Patients with a T-score <  - 1 and/or previous fractures received bisphosphonates. A logistic regression model was used to analyze the risk of fracture. A predictive score for fracture risk was created.

resultsA total of 220 patients evaluated at 1 year of follow-up after LT were included (70% men), mean age 55 + 9.7 years. Before LT, 24% of patients had fragility fractures. Forty-seven percent had osteopenia, and 30% had osteoporosis at the lumbar spine, femoral neck, and total femur. During the first year after LT, 24 (10.9%) patients developed fractures. Age (> 50 years), history of previous fractures, and being a postmenopausal woman were the main risk factors related to incidental fractures. The predictive score for fracture risk based on these variables had a sensitivity of 80% and a specificity of 72%.

conclusionsNearly 11% of the patients developed fragility fractures during the first year after LT, despite following a CP. Identification of high-risk subjects is essential to improve the therapeutic approach in these patients.

Indexed as

Liver TransplantationOsteoporotic FracturesAdultAgedBone DensityBone Density Conservation AgentsClinical ProtocolsFemaleHumansMaleMiddle AgedOsteoporosisPatient Care TeamRetrospective StudiesRisk AssessmentRisk FactorsBone Density Conservation AgentsVitamin DBone fracturesLiver transplantRisk factorsRisk score

Identifiers

PMID40402262

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.