Evidence map›Paper›PMID 40402864›Full record

ReviewJournal of agricultural and food chemistry2025

Plant-Derived Nanovesicles: A Promising Frontier in Tissue Repair and Antiaging.

Yuzhou Zheng, Tangrong Wang, Jiaxin Zhang, Sen Wei, Zhijing Wu, Jiali Li, Beihao Shi, Zixuan Sun, Wenrong Xu, Jian Zhu

Abstract readReview
In one paragraph

Review in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Green nanomedicine for cancer therapy.Chinese medical journal · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Bioinspired engineering ofFrontiers in physiology · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Plant-derived nanovesicles fromFrontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuzhou ZhengVascular Surgery Department, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, China.
Tangrong WangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Jiaxin ZhangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Sen WeiVascular Surgery Department, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, China.
Zhijing WuJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Jiali LiJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Beihao ShiVascular Surgery Department, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, China.
Zixuan SunJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Wenrong XuJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Jian ZhuVascular Surgery Department, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, China.ORCID 0009-0006-7642-9905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, mammal-derived extracellular vesicles (EVs) have been widely used in studies on tissue repair and antiaging. Their therapeutic potential lies in mediating intercellular communication through the transfer of various bioactive molecules. As research on nanovesicles progresses, plant-derived nanovesicles (PDNVs) have attracted growing attention as a promising alternative. As an emerging cross-species regulatory "natural force", PDNVs have attracted considerable interest due to their excellent biocompatibility, low immunogenicity, and remarkable therapeutic effects in tissue injury and aging-related diseases. In this review, we examine the bioactive components, drug delivery potential, and functional mechanisms of PDNVs, and we summarize recent advances in their applications for tissue repair and antiaging. In addition, we systematically discuss the major challenges and limitations hindering the clinical translation and industrialization of PDNVs, and we propose five strategic approaches along with future research directions. This review aims to promote further investigation of PDNVs in regenerative medicine and enhance their potential for clinical application.

Indexed as

AgingExtracellular VesiclesPlant ExtractsPlantsAnimalsDrug Delivery SystemsHumansRegenerative MedicinePlant Extractsantiagingbiomedicine applicationsdamage repairexosomesextracellular vesiclesplant-derived nanovesicles

Identifiers

PMID40402864
PMCPMC12147150

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.