ArticleNeuron2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits.
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Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
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Who cites it
40 citing papers in PubMed.
- From optical control to translational readiness: an evidence-tiered framework for optogenetics in neuromuscular and neurological disorders.Materials today. Bio · 2026Review
- Targeting the peripheral nervous system in adipose tissue with engineered AAV vectors.Cell reports methods · 2026Article
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- δ2-Protocadherins organize parallel indirect basal ganglia circuits.Science advances · 2026Article
- Continuous contributions of the dorsolateral striatum to movement initiation and execution.Science advances · 2026Article
- Learning how to experience the world: From circuits to cell types to genes.Current opinion in neurobiology · 2026Review
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- Genetically Encoded Melanin as a Photostable Scattering Contrast for Whole-Brain Tomography.bioRxiv : the preprint server for biology · 2026Article
- Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026Review
- Multimodal characterization of variation in neuronal types in the mouse basal ganglia.bioRxiv : the preprint server for biology · 2026Article
- Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey.Scientific reports · 2026Article
- Article
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
- Article
- Technical and biological sources of noise confound multiplexed enhancer AAV screening.Nature communications · 2026Article
- A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- CBLN2 promoter enables genetic access to wide-field neurons of the tree shrew superior colliculus.Cell reports methods · 2026Article
- Enhancer-based gene therapy: a new path for precision medicine.Hereditas · 2026Review
- Multi-omic profiling of human and mouse dorsal root ganglia enables targeted gene delivery to nociceptors.bioRxiv : the preprint server for biology · 2026Article
- Article
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Authors and funding
138 authors.
Avery C HunkerAllen Institute for Brain Science, Seattle, WA, USA.
Morgan E WirthlinAllen Institute for Brain Science, Seattle, WA, USA.
Gursajan GillDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Nelson J JohansenAllen Institute for Brain Science, Seattle, WA, USA.
Marcus HooperAllen Institute for Brain Science, Seattle, WA, USA.
Victoria OmsteadAllen Institute for Brain Science, Seattle, WA, USA.
Sara VargasAllen Institute for Brain Science, Seattle, WA, USA.
M Nathaly LermaAllen Institute for Brain Science, Seattle, WA, USA.
Naz TaskinAllen Institute for Brain Science, Seattle, WA, USA.
Natalie WeedAllen Institute for Brain Science, Seattle, WA, USA.
William D LairdAllen Institute for Brain Science, Seattle, WA, USA.
Yemeserach M BishawAllen Institute for Brain Science, Seattle, WA, USA.
Jacqueline L BendrickDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Bryan B GoreAllen Institute for Brain Science, Seattle, WA, USA.
Yoav Ben-SimonAllen Institute for Brain Science, Seattle, WA, USA.
Ximena Opitz-ArayaAllen Institute for Brain Science, Seattle, WA, USA.
Refugio A MartinezAllen Institute for Brain Science, Seattle, WA, USA.
Sharon W WayAllen Institute for Brain Science, Seattle, WA, USA.
Bargavi ThyagarajanAllen Institute for Brain Science, Seattle, WA, USA.
Sven OttoAllen Institute for Brain Science, Seattle, WA, USA.
Raymond E A SanchezAllen Institute for Brain Science, Seattle, WA, USA.
Jason R AlexanderAllen Institute for Brain Science, Seattle, WA, USA.
Avalon AmayaAllen Institute for Neural Dynamics, Seattle, WA, USA.
Adam AmsterAllen Institute for Brain Science, Seattle, WA, USA.
Joel ArbuckleAllen Institute for Brain Science, Seattle, WA, USA.
Angela AyalaAllen Institute for Brain Science, Seattle, WA, USA.
Pam M BakerAllen Institute for Brain Science, Seattle, WA, USA.
Tyler BarcelliAllen Institute for Brain Science, Seattle, WA, USA.
Stuard BartaAllen Institute for Brain Science, Seattle, WA, USA.
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA, USA.
Cameron BielsteinAllen Institute for Brain Science, Seattle, WA, USA.
Prajal BishwakarmaAllen Institute for Brain Science, Seattle, WA, USA.
Jessica BowlusAllen Institute for Brain Science, Seattle, WA, USA.
Gabriella BoyerAllen Institute for Brain Science, Seattle, WA, USA.
Krissy BrounerAllen Institute for Brain Science, Seattle, WA, USA.
Brittny CasianAllen Institute for Brain Science, Seattle, WA, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.
Anish Bhaswanth ChakkaAllen Institute for Brain Science, Seattle, WA, USA.
Rushil ChakrabartyAllen Institute for Brain Science, Seattle, WA, USA.
Peter ChongAllen Institute for Brain Science, Seattle, WA, USA.
Michael ClarkAllen Institute for Brain Science, Seattle, WA, USA.
Kaity ColbertAllen Institute for Brain Science, Seattle, WA, USA.
Scott DanielAllen Institute for Brain Science, Seattle, WA, USA.
Tim DaweAllen Institute for Brain Science, Seattle, WA, USA.
Maxwell DeparteeAllen Institute for Brain Science, Seattle, WA, USA.
Peter DiValentinAllen Institute for Brain Science, Seattle, WA, USA.
Nicholas P DonadioAllen Institute for Brain Science, Seattle, WA, USA.
Nadezhda I DotsonAllen Institute for Brain Science, Seattle, WA, USA.
Deepanjali DwivediAllen Institute for Brain Science, Seattle, WA, USA.
Tom EgdorfAllen Institute for Brain Science, Seattle, WA, USA.
Tim FlissAllen Institute for Brain Science, Seattle, WA, USA.
Amanda GaryAllen Institute for Brain Science, Seattle, WA, USA.
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.
Conor GrassoAllen Institute for Neural Dynamics, Seattle, WA, USA.
Erin L GroceAllen Institute for Brain Science, Seattle, WA, USA.
Kathryn GudsnukAllen Institute for Brain Science, Seattle, WA, USA.
Warren HanAllen Institute for Neural Dynamics, Seattle, WA, USA.
Zeb HaradonAllen Institute for Brain Science, Seattle, WA, USA.
Sam HastingsAllen Institute for Brain Science, Seattle, WA, USA.
Olivia HelbackAllen Institute for Brain Science, Seattle, WA, USA.
Windy V HoAllen Institute for Brain Science, Seattle, WA, USA.
Cindy HuangAllen Institute for Brain Science, Seattle, WA, USA.
Tye JohnsonAllen Institute for Neural Dynamics, Seattle, WA, USA.
Danielle L JonesAllen Institute for Brain Science, Seattle, WA, USA.
Zoe JuneauAllen Institute for Brain Science, Seattle, WA, USA.
Jaimie KenneyAllen Institute for Neural Dynamics, Seattle, WA, USA.
Madison LeiblyAllen Institute for Brain Science, Seattle, WA, USA.
Su LiAllen Institute for Brain Science, Seattle, WA, USA.
Elizabeth LiangAllen Institute for Brain Science, Seattle, WA, USA.
Henry LoefflerAllen Institute for Neural Dynamics, Seattle, WA, USA.
Nicholas A LuskAllen Institute for Brain Science, Seattle, WA, USA.
Zachary MadiganAllen Institute for Brain Science, Seattle, WA, USA.
Jessica MalloyAllen Institute for Brain Science, Seattle, WA, USA.
Jocelin MaloneAllen Institute for Brain Science, Seattle, WA, USA.
Rachel McCueAllen Institute for Brain Science, Seattle, WA, USA.
Jose MelchorAllen Institute for Brain Science, Seattle, WA, USA.
John K MichAllen Institute for Brain Science, Seattle, WA, USA.
Skyler MoosmanAllen Institute for Brain Science, Seattle, WA, USA.
Elyse MorinAllen Institute for Brain Science, Seattle, WA, USA.
Robyn NaidooAllen Institute for Neural Dynamics, Seattle, WA, USA.
Dakota NewmanAllen Institute for Brain Science, Seattle, WA, USA.
Kiet NgoAllen Institute for Brain Science, Seattle, WA, USA.
Katrina NguyenAllen Institute for Neural Dynamics, Seattle, WA, USA.
Aaron L OsterAllen Institute for Brain Science, Seattle, WA, USA.
Ben OuelletteAllen Institute for Neural Dynamics, Seattle, WA, USA.
Alana A OyamaAllen Institute for Brain Science, Seattle, WA, USA.
Nick PenaAllen Institute for Brain Science, Seattle, WA, USA.
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA, USA.
Elliot PhillipsAllen Institute for Brain Science, Seattle, WA, USA.
Christina PomAllen Institute for Brain Science, Seattle, WA, USA.
Lydia PotekhinaAllen Institute for Brain Science, Seattle, WA, USA.
Shea RansfordAllen Institute for Brain Science, Seattle, WA, USA.
Patrick L RayAllen Institute for Brain Science, Seattle, WA, USA.
Melissa RedingAllen Institute for Brain Science, Seattle, WA, USA.
Dean F RetteAllen Institute for Brain Science, Seattle, WA, USA.
Cade ReynoldsonAllen Institute for Brain Science, Seattle, WA, USA.
Christine RimorinAllen Institute for Brain Science, Seattle, WA, USA.
Ana Rios SiglerAllen Institute for Brain Science, Seattle, WA, USA.
Dana B RochaAllen Institute for Brain Science, Seattle, WA, USA.
Kara RonellenfitchAllen Institute for Brain Science, Seattle, WA, USA.
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.
Lane SawyerAllen Institute for Brain Science, Seattle, WA, USA.
Josh P SevignyAllen Institute for Brain Science, Seattle, WA, USA.
Nadiya V ShapovalovaAllen Institute for Brain Science, Seattle, WA, USA.
Noah ShepardAllen Institute for Brain Science, Seattle, WA, USA.
Lyudmila ShulgaAllen Institute for Brain Science, Seattle, WA, USA.
Sherif SolimanAllen Institute for Brain Science, Seattle, WA, USA.
Brian StaatsAllen Institute for Brain Science, Seattle, WA, USA.
Michael J TaorminaAllen Institute for Brain Science, Seattle, WA, USA.
Michael TieuAllen Institute for Brain Science, Seattle, WA, USA.
Yimin WangAllen Institute for Brain Science, Seattle, WA, USA.
Josh WilkesAllen Institute for Neural Dynamics, Seattle, WA, USA.
Toren WoodAllen Institute for Brain Science, Seattle, WA, USA.
Thomas ZhouAllen Institute for Brain Science, Seattle, WA, USA.
Ali WillifordAllen Institute for Neural Dynamics, Seattle, WA, USA.
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.
Tyler MollenkopfAllen Institute for Brain Science, Seattle, WA, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.
Brian E KalmbachAllen Institute for Brain Science, Seattle, WA, USA; Department of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA.
Shenqin YaoAllen Institute for Brain Science, Seattle, WA, USA.
Jeanelle ArizaAllen Institute for Brain Science, Seattle, WA, USA.
Forrest CollmanAllen Institute for Brain Science, Seattle, WA, USA.
Shoaib MuftiAllen Institute for Brain Science, Seattle, WA, USA.
Kimberly SmithAllen Institute for Brain Science, Seattle, WA, USA.
Jack WatersAllen Institute for Brain Science, Seattle, WA, USA.
Ina ErsingAddgene, Watertown, MA, USA.
Marcella PatrickAddgene, Watertown, MA, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, WA, USA; Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
Yoshiko KojimaDepartment of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA.
Greg HorwitzDepartment of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA.
Scott F OwenDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Boaz P LeviAllen Institute for Brain Science, Seattle, WA, USA.
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA, USA; Department of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA.
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.
Trygve E BakkenAllen Institute for Brain Science, Seattle, WA, USA.
Jonathan T TingAllen Institute for Brain Science, Seattle, WA, USA; Department of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA. Electronic address: jonathant@alleninstitute.org.
Funding
Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8MFunctionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9MWaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI CHARLOTTE HOTCHKISS · 2012 to 2026
$34.4MOpen-Access AAV Toolbox for Basal Ganglia Cell Types and CircuitsUF1MH128339 · NIMH · ALLEN INSTITUTE · PI BAKKEN, TRYGVE, DAIGLE, TANYA LYNN · 2021 to 2021
$7.3MMultimodal analysis of primate infragranular pyramidal neurons and their modulationR01NS123959 · NINDS · ALLEN INSTITUTE · PI DEMBROW, NIKOLAI C, KALMBACH, BRIAN E. · 2021 to 2025
$2.8MNeural mechanisms of motor adaptation for an internally driven movementR01EY033760 · NEI · UNIVERSITY OF WASHINGTON · PI Yoshiko Kojima · 2023 to 2026
$1.8MNEI NIH HHS R01 EY033760NIH HHS P51 OD010425NIH HHS U42 OD011123NIMH NIH HHS UF1 MH128339NIMH NIH HHS UM1 MH130981NINDS NIH HHS R01 NS123959
Abstract
We present an enhancer-AAV toolbox for accessing and perturbing striatal cell types and circuits. Best-in-class vectors were curated for accessing major striatal neuron populations including medium spiny neurons (MSNs), direct- and indirect-pathway MSNs, Sst-Chodl, Pvalb-Pthlh, and cholinergic interneurons. Specificity was evaluated by multiple modes of molecular validation, by three different routes of virus delivery, and with diverse transgene cargos. Importantly, we provide detailed information necessary to achieve reliable cell-type-specific labeling under different experimental contexts. We demonstrate direct pathway circuit-selective optogenetic perturbation of behavior and multiplex labeling of striatal interneuron types for targeted analysis of cellular features. Lastly, we show conserved in vivo activity for exemplary MSN enhancers in rats and macaques. This collection of striatal enhancer AAVs offers greater versatility compared to available transgenic lines and can readily be applied for cell type and circuit studies in diverse mammalian species beyond the mouse model.
Indexed as
Corpus StriatumDependovirusEnhancer Elements, GeneticNeuronsAnimalsGenetic VectorsInterneuronsMaleMiceOptogeneticsRatsbasal gangliacaudoputamencholinergicmacaquemedium spiny neuronPvalbspiny projection neuronSst-Chodlstriatonigralstriatopallidal
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LicenceCC BY-NC
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.