Evidence map›Paper›PMID 40404048›Full record

ArticleChest2025

Sputum Cellularity and MRI Ventilation Defects in Severe Asthma.

Hana Serajeddini, Ashutosh Thakar, Melanie Kjarsgaard, Chynna Huang, Nandhitha Ragunayakam, Ekamdeep Sandhu, Carmen Venegas Garrido, Yonni Friedlander, Norm Konyer, Kayla Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hana SerajeddiniFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Ashutosh ThakarFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Melanie KjarsgaardFirestone Institute for Respiratory Health, Hamilton, ON, Canada.
Chynna HuangFirestone Institute for Respiratory Health, Hamilton, ON, Canada.
Nandhitha RagunayakamFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Ekamdeep SandhuFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Carmen Venegas GarridoFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Yonni FriedlanderFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Norm KonyerImaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Kayla ZhangFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Nadia Suray TanFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Katherine RadfordFirestone Institute for Respiratory Health, Hamilton, ON, Canada.
Manali MukherjeeFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Parameswaran NairFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Sarah SvenningsenFirestone Institute for Respiratory Health, Hamilton, ON, Canada; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada; Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. Electronic address: svennins@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAirway inflammation is a hallmark feature of asthma characterized by elevated eosinophils and/or neutrophils. Eosinophils in sputum can contribute to ventilation defects. The functional consequence of other types of cellularity on ventilation is unknown. RESEARCH QUESTION: What is the effect of different sputum cellular phenotypes on abnormal ventilation evaluated by STUDY DESIGN AND

methodsEighty-five patients with severe asthma and 15 healthy control participants underwent

resultsIn patients with asthma, ventilation was abnormal (MRI VDP above the upper limit of normal) for 44% (14 of 32) of those with paucigranulocytic sputum, 64% (14 of 22) with eosinophilic bronchitis, 75% (9 of 12) with neutrophilic bronchitis, and 89% (17 of 19) with mixed-granulocytic bronchitis. Compared to healthy control participants, MRI VDP was higher in participants with asthma with eosinophilic (adjusted P = .0002), neutrophilic (adjusted P = .0001), and mixed-granulocytic phenotypes (adjusted P < .0001) but not a paucigranulocytic phenotype (adjusted P = .051). Among participants with paucigranulocytic asthma, those with an MRI VDP above the upper limit of normal were older (P = .006), had higher fractional exhaled nitric oxide (P = .02), and higher CT mucus scores (P < .0001).

interpretationOur results indicate that in severe asthma, ventilation is abnormal in the presence of intraluminal cellular inflammation, irrespective of phenotype. Abnormal ventilation in paucigranulocytic asthma may be due to airway mucus and was shown to often be associated with elevated fractional exhaled nitric oxide.

Indexed as

AsthmaMagnetic Resonance ImagingSputumAdultCase-Control StudiesEosinophilsFemaleHumansMaleMiddle AgedNeutrophilsSeverity of Illness Indexairway obstructionfractional exhaled nitric oxideinflammationmucusphenotype

Identifiers

PMID40404048
PMCPMC12597553

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.