ArticleRenal failure2025
Renal tubulointerstitial lesions: a prognostic marker in idiopathic membranous nephropathy.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A machine learning model integrating two-dimensional ultrasound radiomics and clinical parameters for differentiating membranous nephropathy from IgA nephropathy.Journal of ultrasound · 2026Article
- Prognostic Stratification in Primary Glomerulonephritis: Integrating Histology, Biomarkers, and Risk Prediction Models.Life (Basel, Switzerland) · 2026Review
- FSTIV score is essential for clinical management and predicts outcome of idiopathic membranous nephropathy.BMC nephrology · 2026Article
- Prognostic value of a composite histologic score in glomerular diseases: a 10-year single center cohort study.BMC nephrology · 2026Article
- A comparative study on the efficacy of rituximab combined with tacrolimus and methylprednisolone in the treatment of patients with moderate-high risk idiopathic membranous nephropathy.American journal of translational research · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
objectiveTo evaluate the impact of renal tubulointerstitial lesions (TIL) on clinical and pathologic outcomes and prognosis in patients with idiopathic membranous nephropathy.
methodsA retrospective cohort study was performed on 582 patients with idiopathic membranous nephropathy. Patients were divided into two groups based on the presence or absence of TIL as determined by renal biopsy: TIL- (258 cases) and TIL+ (324 cases). Kaplan-Meier survival curves and Cox regression models were used to analyze the influence of TIL on renal prognosis. Logistic regression models were used to further identify risk factors associated with the development of TIL.
resultsPatients in the TIL+ group were predominantly male, older, and had a higher prevalence of hypertension, hyperlipidemia, nephrotic syndrome, microscopic hematuria, and immunosuppressive therapy compared to the TIL- group. In addition, triglycerides, blood urea nitrogen, and 24-hour urine protein were significantly higher in the TIL+ group, while albumin and estimated glomerular filtration rate were lower (
conclusionTIL is frequently associated with idiopathic membranous nephropathy, with more severe clinical manifestations and pathologic features, and idiopathic membranous nephropathy patients with TIL have a lower disease remission rate and worse overall renal prognosis. Hypertension, globular/segmental glomerulosclerosis, and intimal thickening of small renal arteries are independent risk factors for the development of TIL in patients with idiopathic membranous nephropathy.
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