ArticleNPJ Parkinson's disease2025
Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The impaired hemodynamics of choroid plexus and its interactions within the glymphatic system in Parkinson's disease.GeroScience · 2026Article
- Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease.CNS neuroscience & therapeutics · 2026Article
- Choroid Plexus Abnormalities in Autoimmune Encephalitis.CNS neuroscience & therapeutics · 2026Article
- A Pilot Study Evaluating the Effect of Artesunate on Glymphatic-Related Fluid Transport in Parkinson's Disease Mouse Models In Vivo and Ex Vivo.CNS neuroscience & therapeutics · 2026Article
- Altered Glymphatic-Related MRI Metrics and Brain Network Reorganization in Drug-Naive Children With Self-Limited Epilepsy With Centrotemporal Spikes.CNS neuroscience & therapeutics · 2026Article
- Divergent Glymphatic Dysfunction and Free Water Pathology Underpin Distinct Mechanisms and Enable Differential Diagnosis in Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Reduced choroid plexus volume aggravates the glymphatic system burden in patients with patent foramen ovale-related migraine with aura.Neuroradiology · 2026Article
- Explainable machine learning identifies candidate shared neuroanatomical features in Alzheimer's and Parkinson's via importance inversion transfer.bioRxiv : the preprint server for biology · 2026Article
- Association of choroid plexus volume with brain atrophy and glucose metabolism in multiple system atrophy.Scientific reports · 2026Article
- BAP31 Modulates Mitochondrial Homeostasis Through PINK1/Parkin Pathway in MPTP Parkinsonism Mouse Models.Cells · 2026Article
- Automated synthetic contrast-enhanced MRI improves choroid plexus segmentation in Parkinsonian syndromes.Radiology advances · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson's disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.