Evidence mapPaperPMID 40404778Full record

ArticleScientific reports2025

Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors.

Fariba Peytam, Parham Foroumadi, Hayrettin Ozan Gulcan, Maryam Norouzbahari, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fahimeh Ghasemi, Mohammadreza Torabi, Behnaz Bameri, Maliheh Barazandeh Tehrani and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fariba PeytamDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Parham ForoumadiInternational Campus-School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Hayrettin Ozan GulcanFaculty of Pharmacy, Eastern Mediterranean University, via Mersin 10, Famagusta, TRNC, Turkey.
Maryam NorouzbahariFaculty of Pharmacy, Final International University, Kyrenia via Mersin 10 Turkey, Catalkoy, TRNC, Turkey.
Somayeh MojtabaviDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Ali FaramarziDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Fahimeh GhasemiDepartment of Bioinformatics and Systems Biology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammadreza TorabiDepartment of Bioinformatics and Systems Biology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Behnaz BameriDepartment of Toxicology and Pharmacology, Faculty of Pharmacy and Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Maliheh Barazandeh TehraniDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Loghman FiroozpourDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. firoozpour@gmail.com.
Alireza ForoumadiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target in the treatment of type 2 diabetes mellitus. Present work introduces

Indexed as

alpha-GlucosidasesDrug DesignGlycoside Hydrolase InhibitorsPyridinesTriazolesCatalytic DomainHumansMolecular Docking SimulationStructure-Activity Relationshipalpha-GlucosidasesGlycoside Hydrolase InhibitorsPyridinesTriazoles[1,2,4]Triazolo[1,5-a]pyridineMachine learning modelα-Amylaseα-Glucosidase

Identifiers

PMID40404778
PMCPMC12098659

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.