Evidence map›Paper›PMID 40404894›Full record

ArticleNature cell biology2025

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation.

Subhash B Arya, Samuel P Collie, Yang Xu, Martin Fernandez, Jonathan Z Sexton, Shyamal Mosalaganti, Pierre A Coulombe, Carole A Parent

Abstract read
In one paragraph

Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. cPLAScience advances · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
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  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Subhash B AryaLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5671-8666
Samuel P Collie *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Yang Xu *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Martin FernandezLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Jonathan Z SextonDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Shyamal MosalagantiLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5934-687X
Pierre A CoulombeDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-0680-2373
Carole A ParentLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA. parentc@umich.edu.ORCID http://orcid.org/0000-0002-1518-1452

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Signal relay during directed cell migrationR01AI152517 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANSON, PHYLLIS I, PARENT, CAROLE ANNE · 2020 to 2024
$2.6M
In-situ architecture of membrane contact sites mediating organelle fissionDP2GM150019 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOSALAGANTI, SHYAMAL · 2022 to 2025
$2.3M
Training Program in Translational ResearchT32GM141840 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREW P LIEBERMAN, Zaneta Nikolovska-Coleska · 2021 to 2026
$2.0M
Keratinocyte-dependent regulation of innate immune responses in inflamed skinR01AR083222 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pierre Coulombe, Carole Anne Parent · 2024 to 2026
$1.7M
Laser-based high content imaging microscopeS10OD034245 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEXTON, JONATHAN ZACHARY · 2024 to 2024
$1.4M
NCI NIH HHS P30 CA046592NIAID NIH HHS R01 AI152517NIAMS NIH HHS R01 AR083222NIGMS NIH HHS DP2 GM150019NIGMS NIH HHS T32 GM141840NIGMS NIH HHS T32 GM145470NIH HHS S10 OD034245
6 · The paper itself

Abstract

Acute inflammation, characterized by a rapid influx of neutrophils, is a protective response that can lead to chronic inflammatory diseases when left unresolved. We previously showed that secretion of LTB

Indexed as

DNAExosomesInflammationNeutrophil InfiltrationNeutrophilsAnimalsDisease Models, AnimalExtracellular TrapsHumansMiceMice, Inbred C57BLMice, KnockoutMultivesicular BodiesNeutrophil ActivationNuclear EnvelopeSkinDNA

Identifiers

PMID40404894
PMCPMC12206380

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.