Evidence map›Paper›PMID 40405046›Full record

ArticleMolecular imaging and biology2025

Targeted Radionuclide Therapy Using a Lutetium-177 Labeled Human Anti-CD133 Antibody.

Kevin Wyszatko, Nancy Janzen, Napoleon Law, Manuela Ventura, Teesha Komal, Neil Savage, Chitra Venugopal, Jacek M Kwiecien, Sheila K Singh, Saman Sadeghi

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kevin WyszatkoDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Nancy JanzenDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Napoleon LawSpatio-Temporal Targeting and Amplification of Radiation Response Innovation Centre (STTARR), University Health Network, Toronto, ON, Canada.
Manuela VenturaSpatio-Temporal Targeting and Amplification of Radiation Response Innovation Centre (STTARR), University Health Network, Toronto, ON, Canada.
Teesha KomalSpatio-Temporal Targeting and Amplification of Radiation Response Innovation Centre (STTARR), University Health Network, Toronto, ON, Canada.
Neil SavageCentre for Discovery in Cancer Research, McMaster University, Hamilton, ON, Canada.
Chitra VenugopalCentre for Discovery in Cancer Research, McMaster University, Hamilton, ON, Canada.
Jacek M KwiecienDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Sheila K SinghCentre for Discovery in Cancer Research, McMaster University, Hamilton, ON, Canada.
Saman SadeghiDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada. sadegs10@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTargeted radionuclide therapy against cancer stem cell-specific markers, such as CD133, constitutes a promising strategy to eliminate resilient cancer stem cells for improved outcomes in refractory tumors. Here, we report the synthesis and evaluation of [ PROCEDURES: A fully human, anti-CD133 antibody (RW03) was conjugated with DOTA-NHS and radiolabeled with lutetium-177 to yield [

resultsRadioimmunoconjugate [

conclusionsThese findings underscore the potential of [

Indexed as

AC133 AntigenAntibodies, MonoclonalLutetiumRadioimmunotherapyRadioisotopesAnimalsFemaleHT29 CellsHumansImmunoconjugatesMiceTissue DistributionTomography, Emission-Computed, Single-PhotonXenograft Model Antitumor AssaysAC133 AntigenAntibodies, MonoclonalImmunoconjugatesLutetiumLutetium-177RadioisotopesCancer stem cellCD133RadioimmunotherapyTargeted radionuclide therapy

Identifiers

PMID40405046

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.